ARHGEF12

Entrez Summary: Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli working through G protein-coupled receptors. The encoded protein may form a complex with G proteins and stimulate Rho-dependent signals. This protein has been observed to form a myeloid/lymphoid fusion partner in acute myeloid leukemia. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014].
UniProt Summary: May play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13). Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase and may act as GTPase-activating protein (GAP) for GNA12 and GNA13. {ECO:0000269|PubMed:11094164}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
Actinomycin-D 0.001μM R00 exp3	1.8
Phenformin 20μM R05 exp212	1.93

G protein-coupled receptor binding
Rho guanyl-nucleotide exchange factor activity
Rho protein signal transduction
regulation of Rho protein signal transduction
regulation of Ras protein signal transduction
Ras protein signal transduction
GTPase activator activity
small GTPase mediated signal transduction
regulation of small GTPase mediated signal transduction
positive regulation of GTPase activity
regulation of GTPase activity
positive regulation of apoptotic process
positive regulation of programmed cell death
positive regulation of cell death
positive regulation of hydrolase activity
regulation of hydrolase activity
G protein-coupled receptor signaling pathway
positive regulation of catalytic activity
regulation of apoptotic process
regulation of programmed cell death
regulation of cell death
intracellular signal transduction
positive regulation of molecular function
regulation of intracellular signal transduction
membrane