ARHGEF28 [The Human Chemical-Genetic Interaction Map Project]

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======= ARHGEF28 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ARHGEF28
  * **<color #00a2e8>Official Name</color>**: Rho guanine nucleotide exchange factor 28
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=64283|64283]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8N1W1|Q8N1W1]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ARHGEF28&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ARHGEF28|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/612790|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the Rho guanine nucleotide exchange factor family. The encoded protein interacts with low molecular weight neurofilament mRNA and may be involved in the formation of amyotrophic lateral sclerosis neurofilament aggregates. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Apr 2010]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|RhoGEF|
|C1 1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|Rho guanyl-nucleotide exchange factor activity|
|ephrin receptor signaling pathway|
|guanyl-nucleotide exchange factor activity|
|regulation of Rho protein signal transduction|
|regulation of Ras protein signal transduction|
|regulation of small GTPase mediated signal transduction|
|transmembrane receptor protein tyrosine kinase signaling pathway|
|enzyme linked receptor protein signaling pathway|
|RNA binding|
|intracellular signal transduction|
|regulation of intracellular signal transduction|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp224|CB-839 10μM R05 exp224]]|-2.1|
|[[:results:exp96|BI-2536 0.02μM R03 exp96]]|-1.8|
|[[:results:exp508|NN-Dimethylsphingosine 2.5μM R08 exp508]]|1.97|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 9933
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 0.25 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ARHGEF28 Expression in NALM6 Cells: 0.25'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>