ARHGEF28

Entrez Summary: This gene encodes a member of the Rho guanine nucleotide exchange factor family. The encoded protein interacts with low molecular weight neurofilament mRNA and may be involved in the formation of amyotrophic lateral sclerosis neurofilament aggregates. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Apr 2010].
UniProt Summary: N/A

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
CB-839 10μM R05 exp224	-2.1
BI-2536 0.02μM R03 exp96	-1.8
NN-Dimethylsphingosine 2.5μM R08 exp508	1.97

RhoGEF
C1 1

Rho guanyl-nucleotide exchange factor activity
ephrin receptor signaling pathway
guanyl-nucleotide exchange factor activity
regulation of Rho protein signal transduction
regulation of Ras protein signal transduction
regulation of small GTPase mediated signal transduction
transmembrane receptor protein tyrosine kinase signaling pathway
enzyme linked receptor protein signaling pathway
RNA binding
intracellular signal transduction
regulation of intracellular signal transduction