ARL6IP5
Gene Information
- Official Symbol: ARL6IP5
- Official Name: ADP ribosylation factor like GTPase 6 interacting protein 5
- Aliases and Previous Symbols: N/A
- Entrez ID: 10550
- UniProt: O75915
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Regulates intracellular concentrations of taurine and glutamate. Negatively modulates SLC1A1/EAAC1 glutamate transport activity by decreasing its affinity for glutamate in a PKC activity-dependent manner. May be involved in membrane traffic. {ECO:0000250|UniProtKB:Q8R5J9, ECO:0000250|UniProtKB:Q9ES40}.
Pfam Domains GO Terms
Pfam Domains
| PRA1 |
GO Terms
| negative regulation of L-glutamate import across plasma membrane |
| regulation of L-glutamate import across plasma membrane |
| negative regulation of neurotransmitter uptake |
| regulation of amino acid transmembrane transport |
| regulation of amino acid import across plasma membrane |
| negative regulation of amino acid transport |
| negative regulation of mitochondrial membrane potential |
| negative regulation of membrane potential |
| negative regulation of anion transmembrane transport |
| intrinsic apoptotic signaling pathway in response to oxidative stress |
| L-glutamate transmembrane transport |
| negative regulation of organic acid transport |
| regulation of neurotransmitter uptake |
| cell death in response to oxidative stress |
| negative regulation of neurotransmitter transport |
| negative regulation of amine transport |
| regulation of anion transmembrane transport |
| negative regulation of response to drug |
| negative regulation of anion transport |
| regulation of amino acid transport |
| L-alpha-amino acid transmembrane transport |
| acidic amino acid transport |
| regulation of organic acid transport |
| L-amino acid transport |
| drug transmembrane transport |
| regulation of mitochondrial membrane potential |
| amino acid transmembrane transport |
| dicarboxylic acid transport |
| regulation of amine transport |
| regulation of anion transport |
| negative regulation of ion transmembrane transport |
| regulation of response to drug |
| negative regulation of transmembrane transport |
| amino acid transport |
| carboxylic acid transmembrane transport |
| organic acid transmembrane transport |
| positive regulation of cysteine-type endopeptidase activity involved in apoptotic process |
| regulation of neurotransmitter transport |
| negative regulation of ion transport |
| drug transport |
| intrinsic apoptotic signaling pathway |
| positive regulation of cysteine-type endopeptidase activity |
| positive regulation of stress-activated MAPK cascade |
| positive regulation of stress-activated protein kinase signaling cascade |
| positive regulation of endopeptidase activity |
| neurotransmitter transport |
| positive regulation of peptidase activity |
| regulation of cysteine-type endopeptidase activity involved in apoptotic process |
| regulation of stress-activated MAPK cascade |
| regulation of stress-activated protein kinase signaling cascade |
| cellular response to oxidative stress |
| regulation of cysteine-type endopeptidase activity |
| anion transmembrane transport |
| apoptotic signaling pathway |
| organic acid transport |
| carboxylic acid transport |
| regulation of neurotransmitter levels |
| positive regulation of proteolysis |
| cytoskeleton |
| response to oxidative stress |
| regulation of endopeptidase activity |
| regulation of membrane potential |
| regulation of peptidase activity |
| organic anion transport |
| regulation of ion transmembrane transport |
| negative regulation of transport |
| positive regulation of MAPK cascade |
| regulation of transmembrane transport |
| anion transport |
| positive regulation of apoptotic process |
| positive regulation of programmed cell death |
| positive regulation of cell death |
| regulation of ion transport |
| regulation of proteolysis |
| regulation of cellular response to stress |
| regulation of MAPK cascade |
| molecular function |
| positive regulation of hydrolase activity |
| apoptotic process |
| endoplasmic reticulum membrane |
| ion transmembrane transport |
| positive regulation of protein phosphorylation |
| positive regulation of intracellular signal transduction |
| response to drug |
| programmed cell death |
| positive regulation of phosphorylation |
| cell death |
| positive regulation of phosphorus metabolic process |
| positive regulation of phosphate metabolic process |
| positive regulation of protein modification process |
| regulation of hydrolase activity |
| transmembrane transport |
| ion transport |
| positive regulation of catalytic activity |
| regulation of protein phosphorylation |
| regulation of response to stress |
| regulation of apoptotic process |
| regulation of programmed cell death |
| regulation of phosphorylation |
| positive regulation of cellular protein metabolic process |
| negative regulation of response to stimulus |
| positive regulation of signal transduction |
| regulation of cell death |
| intracellular signal transduction |
| cellular response to stress |
| positive regulation of protein metabolic process |
| positive regulation of molecular function |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| positive regulation of cell communication |
| positive regulation of signaling |
| regulation of intracellular signal transduction |
| nitrogen compound transport |
| regulation of protein modification process |
| regulation of transport |
| membrane |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
No hits were found.
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 13825
- Expression level (log2 read counts): 5.31
Expression Distribution
ARL6IP5 Expression in NALM6 Cells: 5.31
