ARL8B

Entrez Summary: N/A
UniProt Summary: May play a role in lysosome motility (PubMed:16537643, PubMed:25898167). May play a role in chromosome segregation (PubMed:15331635). {ECO:0000269|PubMed:15331635, ECO:0000269|PubMed:16537643, ECO:0000269|PubMed:25898167}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 1/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	1/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
Betulinic acid 10 to 15μM on day4 R05 exp222	-3.05
Cerivastatin 0.15μM R05 exp226	1.87

spindle midzone
vacuolar membrane
beta-tubulin binding
alpha-tubulin binding
anterograde axonal transport
lysosome localization
axonal transport
axon cytoplasm
axo-dendritic transport
GDP binding
late endosome membrane
transport along microtubule
midbody
cytoskeleton-dependent intracellular transport
microtubule-based transport
synapse
microtubule-based movement
chromosome segregation
lysosomal membrane
GTPase activity
GTP binding
cell division
cell junction
organelle localization
microtubule-based process
cell cycle
protein transport
intracellular transport
peptide transport
movement of cell or subcellular component
amide transport
establishment of protein localization
establishment of localization in cell
nitrogen compound transport
membrane