ARNT2

Entrez Summary: N/A
UniProt Summary: Transcription factor that plays a role in the development of the hypothalamo-pituitary axis, postnatal brain growth, and visual and renal function (PubMed:24022475). Specifically recognizes the xenobiotic response element (XRE). {ECO:0000269|PubMed:24022475}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
Isoniazid 100μM R08 exp494	-1.9
CCCP 0.1μM R00 exp10	-1.73

aryl hydrocarbon receptor binding
xenobiotic metabolic process
response to estradiol
cellular response to xenobiotic stimulus
transcription factor complex
response to xenobiotic stimulus
response to hypoxia
response to decreased oxygen levels
in utero embryonic development
response to oxygen levels
DNA-binding transcription activator activity, RNA polymerase II-specific
protein heterodimerization activity
RNA polymerase II proximal promoter sequence-specific DNA binding
chordate embryonic development
embryo development ending in birth or egg hatching
DNA-binding transcription factor activity
brain development
head development
response to lipid
negative regulation of apoptotic process
negative regulation of programmed cell death
response to hormone
positive regulation of cell population proliferation
response to organic cyclic compound
embryo development
central nervous system development
negative regulation of cell death
response to abiotic stimulus
positive regulation of transcription by RNA polymerase II
response to endogenous stimulus
regulation of apoptotic process
positive regulation of transcription, DNA-templated
response to oxygen-containing compound
DNA-binding transcription factor activity, RNA polymerase II-specific
regulation of programmed cell death
regulation of cell population proliferation
positive regulation of nucleic acid-templated transcription
positive regulation of RNA biosynthetic process
regulation of cell death
positive regulation of RNA metabolic process