ARPC1B

Gene Information

Official Symbol: ARPC1B
Official Name: actin related protein 2/3 complex subunit 1B
Aliases and Previous Symbols: N/A
Entrez ID: 10095
UniProt: O15143
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene encodes one of seven subunits of the human Arp2/3 protein complex. This subunit is a member of the SOP2 family of proteins and is most similar to the protein encoded by gene ARPC1A. The similarity between these two proteins suggests that they both may function as p41 subunit of the human Arp2/3 complex that has been implicated in the control of actin polymerization in cells. It is possible that the p41 subunit is involved in assembling and maintaining the structure of the Arp2/3 complex. Multiple versions of the p41 subunit may adapt the functions of the complex to different cell types or developmental stages. This protein also has a role in centrosomal homeostasis by being an activator and substrate of the Aurora A kinase. [provided by RefSeq, Mar 2011].
UniProt Summary: Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 11155
Expression level (log2 read counts): 6.36

Expression Distribution

tubulobulbar complex
Arp2/3 protein complex
Arp2/3 complex-mediated actin nucleation
actin nucleation
response to estrogen
ephrin receptor signaling pathway
positive regulation of actin filament polymerization
structural constituent of cytoskeleton
positive regulation of protein polymerization
immune response-regulating cell surface receptor signaling pathway involved in phagocytosis
response to estradiol
Fc-gamma receptor signaling pathway involved in phagocytosis
Fc receptor mediated stimulatory signaling pathway
Fc-gamma receptor signaling pathway
regulation of actin filament polymerization
regulation of actin polymerization or depolymerization
regulation of actin filament length
positive regulation of supramolecular fiber organization
actin filament binding
actin cytoskeleton
positive regulation of cytoskeleton organization
regulation of protein polymerization
actin filament organization
Fc receptor signaling pathway
positive regulation of protein complex assembly
regulation of actin filament organization
phagocytosis
regulation of actin cytoskeleton organization
regulation of supramolecular fiber organization
regulation of cellular component size
regulation of actin filament-based process
focal adhesion
immune response-activating cell surface receptor signaling pathway
regulation of protein complex assembly
supramolecular fiber organization
immune response-regulating cell surface receptor signaling pathway
actin cytoskeleton organization
transmembrane receptor protein tyrosine kinase signaling pathway
regulation of anatomical structure size
positive regulation of cellular component biogenesis