ARPP19 [The Human Chemical-Genetic Interaction Map Project]

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======= ARPP19 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ARPP19
  * **<color #00a2e8>Official Name</color>**: cAMP regulated phosphoprotein 19
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10776|10776]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P56211|P56211]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ARPP19&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ARPP19|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605487|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. When phosphorylated at Ser-62 during mitosis, specifically interacts with PPP2R2D (PR55-delta) and inhibits its activity, leading to inactivation of PP2A, an essential condition to keep cyclin-B1-CDK1 activity high during M phase. May indirectly enhance GAP-43 expression. {ECO:0000269|PubMed:21164014}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Endosulfine|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|phosphatase inhibitor activity|
|positive regulation of gluconeogenesis|
|protein phosphatase 2A binding|
|protein phosphatase regulator activity|
|protein phosphatase inhibitor activity|
|positive regulation of glucose import|
|positive regulation of glucose metabolic process|
|potassium channel regulator activity|
|positive regulation of glucose transmembrane transport|
|regulation of gluconeogenesis|
|regulation of glucose import|
|positive regulation of cellular carbohydrate metabolic process|
|negative regulation of phosphoprotein phosphatase activity|
|negative regulation of protein dephosphorylation|
|regulation of glucose transmembrane transport|
|positive regulation of carbohydrate metabolic process|
|regulation of carbohydrate biosynthetic process|
|negative regulation of phosphatase activity|
|negative regulation of dephosphorylation|
|regulation of glucose metabolic process|
|regulation of phosphoprotein phosphatase activity|
|G2/M transition of mitotic cell cycle|
|cell cycle G2/M phase transition|
|positive regulation of small molecule metabolic process|
|regulation of cellular carbohydrate metabolic process|
|regulation of protein dephosphorylation|
|regulation of phosphatase activity|
|positive regulation of transmembrane transport|
|regulation of carbohydrate metabolic process|
|regulation of dephosphorylation|
|mitotic cell cycle phase transition|
|cell cycle phase transition|
|signaling receptor binding|
|regulation of small molecule metabolic process|
|negative regulation of hydrolase activity|
|cell division|
|negative regulation of phosphate metabolic process|
|negative regulation of phosphorus metabolic process|
|regulation of transmembrane transport|
|negative regulation of protein modification process|
|mitotic cell cycle process|
|mitotic cell cycle|
|negative regulation of catalytic activity|
|positive regulation of transport|
|cell cycle process|
|negative regulation of cellular protein metabolic process|
|negative regulation of protein metabolic process|
|negative regulation of molecular function|
|regulation of hydrolase activity|
|cell cycle|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of protein modification process|
|regulation of transport|
|positive regulation of cellular biosynthetic process|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp293|Myriocin 25μM R06 exp293]]|-1.95|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hgc6.3|HGC6.3]]|0.443|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|1/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 13739
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.67 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ARPP19 Expression in NALM6 Cells: 7.67'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>