ARPP19

Gene Information

Official Symbol: ARPP19
Official Name: cAMP regulated phosphoprotein 19
Aliases and Previous Symbols: N/A
Entrez ID: 10776
UniProt: P56211
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. When phosphorylated at Ser-62 during mitosis, specifically interacts with PPP2R2D (PR55-delta) and inhibits its activity, leading to inactivation of PP2A, an essential condition to keep cyclin-B1-CDK1 activity high during M phase. May indirectly enhance GAP-43 expression. {ECO:0000269|PubMed:21164014}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 1/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	1/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 13739
Expression level (log2 read counts): 7.67

Expression Distribution

phosphatase inhibitor activity
positive regulation of gluconeogenesis
protein phosphatase 2A binding
protein phosphatase regulator activity
protein phosphatase inhibitor activity
positive regulation of glucose import
positive regulation of glucose metabolic process
potassium channel regulator activity
positive regulation of glucose transmembrane transport
regulation of gluconeogenesis
regulation of glucose import
positive regulation of cellular carbohydrate metabolic process
negative regulation of phosphoprotein phosphatase activity
negative regulation of protein dephosphorylation
regulation of glucose transmembrane transport
positive regulation of carbohydrate metabolic process
regulation of carbohydrate biosynthetic process
negative regulation of phosphatase activity
negative regulation of dephosphorylation
regulation of glucose metabolic process
regulation of phosphoprotein phosphatase activity
G2/M transition of mitotic cell cycle
cell cycle G2/M phase transition
positive regulation of small molecule metabolic process
regulation of cellular carbohydrate metabolic process
regulation of protein dephosphorylation
regulation of phosphatase activity
positive regulation of transmembrane transport
regulation of carbohydrate metabolic process
regulation of dephosphorylation
mitotic cell cycle phase transition
cell cycle phase transition
signaling receptor binding
regulation of small molecule metabolic process
negative regulation of hydrolase activity
cell division
negative regulation of phosphate metabolic process
negative regulation of phosphorus metabolic process
regulation of transmembrane transport
negative regulation of protein modification process