ARRDC3 [The Human Chemical-Genetic Interaction Map Project]

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======= ARRDC3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ARRDC3
  * **<color #00a2e8>Official Name</color>**: arrestin domain containing 3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=57561|57561]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q96B67|Q96B67]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ARRDC3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ARRDC3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/612464|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the arrestin family of proteins, which regulate G protein-mediated signaling. The encoded protein is thought to act as a regulator of breast cancer growth and progression by binding to a phosphorylated form of integrin beta4, a tumor-related antigen, targeting the integrin for internalization and degradation. [provided by RefSeq, Jul 2016]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Adapter protein that plays a role in regulating cell- surface expression of adrenergic receptors and probably also other G protein-coupled receptors (PubMed:20559325, PubMed:21982743, PubMed:23208550). Plays a role in NEDD4-mediated ubiquitination and endocytosis af activated ADRB2 and subsequent ADRB2 degradation (PubMed:20559325, PubMed:23208550). May recruit NEDD4 to ADRB2 (PubMed:20559325). Alternatively, may function as adapter protein that does not play a major role in recruiting NEDD4 to ADRB2, but rather plays a role in a targeting ADRB2 to endosomes (PubMed:23208550). {ECO:0000269|PubMed:20559325, ECO:0000269|PubMed:23208550}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Arrestin N|
|Arrestin C|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|beta-3 adrenergic receptor binding|
|negative regulation of heat generation|
|negative regulation of locomotion involved in locomotory behavior|
|negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway|
|regulation of locomotion involved in locomotory behavior|
|fat pad development|
|negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway|
|regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway|
|regulation of heat generation|
|negative regulation of behavior|
|negative regulation of cAMP-mediated signaling|
|temperature homeostasis|
|positive regulation of ubiquitin-protein transferase activity|
|adipose tissue development|
|negative regulation of G protein-coupled receptor signaling pathway|
|negative regulation of cold-induced thermogenesis|
|regulation of cAMP-mediated signaling|
|regulation of ubiquitin-protein transferase activity|
|regulation of behavior|
|positive regulation of protein ubiquitination|
|positive regulation of protein modification by small protein conjugation or removal|
|regulation of G protein-coupled receptor signaling pathway|
|regulation of cold-induced thermogenesis|
|regulation of protein ubiquitination|
|connective tissue development|
|regulation of protein modification by small protein conjugation or removal|
|lysosome|
|early endosome|
|endosome|
|negative regulation of locomotion|
|multicellular organismal homeostasis|
|skin development|
|negative regulation of intracellular signal transduction|
|positive regulation of transferase activity|
|regulation of transferase activity|
|regulation of locomotion|
|negative regulation of multicellular organismal process|
|positive regulation of protein modification process|
|negative regulation of signal transduction|
|negative regulation of cell communication|
|negative regulation of signaling|
|positive regulation of catalytic activity|
|positive regulation of cellular protein metabolic process|
|negative regulation of response to stimulus|
|homeostatic process|
|positive regulation of protein metabolic process|
|tissue development|
|positive regulation of molecular function|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp33|Rotenone 2μM R00 exp33]]|-1.99|
|[[:results:exp374|Latrunculin-B 10μM R07 exp374]]|-1.75|
|[[:results:exp466|Cannabidiol 20μM R08 exp466]]|1.71|
|[[:results:exp159|Docetaxel 0.001 to 0.002μM on day4 R04 exp159]]|1.73|
|[[:results:exp510|Nicotine 3000μM R08 exp510]]|1.73|
|[[:results:exp218|A-395 10μM R05 exp218]]|1.77|
|[[:results:exp492|iCRT14 30μM R08 exp492]]|1.77|
|[[:results:exp463|Caffeine 2600μM R08 exp463]]|1.78|
|[[:results:exp224|CB-839 10μM R05 exp224]]|1.8|
|[[:results:exp474|CR131-b 0.005μM R08 exp474]]|1.83|
|[[:results:exp152|SGC2043 10μM R03 exp152]]|1.86|
|[[:results:exp47|Lapatinib 5μM R01 exp47]]|1.88|
|[[:results:exp219|A-395N 10μM R05 exp219]]|1.89|
|[[:results:exp456|Benzoate 20000μM R08 exp456]]|1.92|
|[[:results:exp242|Radicicol 0.16μM R05 exp242]]|1.92|
|[[:results:exp468|CB-5083 0.4μM R08 exp468]]|1.96|
|[[:results:exp409|THZ531 0.11μM R07 exp409]]|1.98|
|[[:results:exp67|BVD-523 15μM R02 exp67]]|2|
|[[:results:exp215|Colchicine 0.009μM R05 exp215]]|2|
|[[:results:exp444|THZ531 0.225μM R08 exp444]]|2.01|
|[[:results:exp275|Citral 75μM R06 exp275]]|2.04|
|[[:results:exp500|LY2090314 0.003μM R08 exp500 no dilution day6]]|2.05|
|[[:results:exp148|SB202190 10μM R03 exp148]]|2.05|
|[[:results:exp102|Nifuroxazide 5μM R03 exp102]]|2.11|
|[[:results:exp238|Parthenolide 2.5μM R05 exp238]]|2.16|
|[[:results:exp356|Docosahexaenoic-acid 50μM R07 exp356]]|2.29|
|[[:results:exp175|3-Bromopyruvate 7μM R04 exp175]]|2.33|
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|2.33|
|[[:results:exp53|Suberoylanilide-Hydroxamic-Acid 0.02μM R01 exp53]]|2.54|
|[[:results:exp48|Mubritinib 0.2μM R01 exp48]]|2.7|
|[[:results:exp292|Menadione 5μM R06 exp292]]|2.81|
|[[:results:exp274|Citral 50μM R06 exp274]]|4.58|
|[[:results:exp234|Ethanol 0.01 R05 exp234]]|4.74|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hgc6.3|HGC6.3]]|0.47|
|[[:human genes:m:mdh1|MDH1]]|0.419|
|[[:human genes:p:pds5a|PDS5A]]|0.407|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 17744
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.14 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ARRDC3 Expression in NALM6 Cells: 6.14'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>