ARRDC3

Gene Information

Official Symbol: ARRDC3
Official Name: arrestin domain containing 3
Aliases and Previous Symbols: N/A
Entrez ID: 57561
UniProt: Q96B67
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene encodes a member of the arrestin family of proteins, which regulate G protein-mediated signaling. The encoded protein is thought to act as a regulator of breast cancer growth and progression by binding to a phosphorylated form of integrin beta4, a tumor-related antigen, targeting the integrin for internalization and degradation. [provided by RefSeq, Jul 2016].
UniProt Summary: Adapter protein that plays a role in regulating cell- surface expression of adrenergic receptors and probably also other G protein-coupled receptors (PubMed:20559325, PubMed:21982743, PubMed:23208550). Plays a role in NEDD4-mediated ubiquitination and endocytosis af activated ADRB2 and subsequent ADRB2 degradation (PubMed:20559325, PubMed:23208550). May recruit NEDD4 to ADRB2 (PubMed:20559325). Alternatively, may function as adapter protein that does not play a major role in recruiting NEDD4 to ADRB2, but rather plays a role in a targeting ADRB2 to endosomes (PubMed:23208550). {ECO:0000269|PubMed:20559325, ECO:0000269|PubMed:23208550}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Rotenone 2μM R00 exp33	-1.99
Latrunculin-B 10μM R07 exp374	-1.75
Cannabidiol 20μM R08 exp466	1.71
Docetaxel 0.001 to 0.002μM on day4 R04 exp159	1.73
Nicotine 3000μM R08 exp510	1.73
A-395 10μM R05 exp218	1.77
iCRT14 30μM R08 exp492	1.77
Caffeine 2600μM R08 exp463	1.78
CB-839 10μM R05 exp224	1.8
CR131-b 0.005μM R08 exp474	1.83
SGC2043 10μM R03 exp152	1.86
Lapatinib 5μM R01 exp47	1.88
A-395N 10μM R05 exp219	1.89
Benzoate 20000μM R08 exp456	1.92
Radicicol 0.16μM R05 exp242	1.92
CB-5083 0.4μM R08 exp468	1.96
THZ531 0.11μM R07 exp409	1.98
BVD-523 15μM R02 exp67	2
Colchicine 0.009μM R05 exp215	2
THZ531 0.225μM R08 exp444	2.01
Citral 75μM R06 exp275	2.04
LY2090314 0.003μM R08 exp500 no dilution day6	2.05
SB202190 10μM R03 exp148	2.05
Nifuroxazide 5μM R03 exp102	2.11
Parthenolide 2.5μM R05 exp238	2.16
Docosahexaenoic-acid 50μM R07 exp356	2.29
3-Bromopyruvate 7μM R04 exp175	2.33
Thimerosal 0.85μM R08 exp529	2.33
Suberoylanilide-Hydroxamic-Acid 0.02μM R01 exp53	2.54
Mubritinib 0.2μM R01 exp48	2.7
Menadione 5μM R06 exp292	2.81
Citral 50μM R06 exp274	4.58
Ethanol 0.01 R05 exp234	4.74

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 17744
Expression level (log2 read counts): 6.14

Expression Distribution

Gene	Correlation
HGC6.3	0.47
MDH1	0.419
PDS5A	0.407

Arrestin N
Arrestin C

beta-3 adrenergic receptor binding
negative regulation of heat generation
negative regulation of locomotion involved in locomotory behavior
negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway
regulation of locomotion involved in locomotory behavior
fat pad development
negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway
regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway
regulation of heat generation
negative regulation of behavior
negative regulation of cAMP-mediated signaling
temperature homeostasis
positive regulation of ubiquitin-protein transferase activity
adipose tissue development
negative regulation of G protein-coupled receptor signaling pathway
negative regulation of cold-induced thermogenesis
regulation of cAMP-mediated signaling
regulation of ubiquitin-protein transferase activity
regulation of behavior
positive regulation of protein ubiquitination
positive regulation of protein modification by small protein conjugation or removal
regulation of G protein-coupled receptor signaling pathway
regulation of cold-induced thermogenesis
regulation of protein ubiquitination
connective tissue development
regulation of protein modification by small protein conjugation or removal
lysosome
early endosome
endosome
negative regulation of locomotion
multicellular organismal homeostasis
skin development
negative regulation of intracellular signal transduction
positive regulation of transferase activity
regulation of transferase activity
regulation of locomotion
negative regulation of multicellular organismal process
positive regulation of protein modification process
negative regulation of signal transduction
negative regulation of cell communication