ARTN

Entrez Summary: N/A
UniProt Summary: Ligand for the GFR-alpha-3-RET receptor complex but can also activate the GFR-alpha-1-RET receptor complex. Supports the survival of sensory and sympathetic peripheral neurons in culture and also supports the survival of dopaminergic neurons of the ventral mid-brain. Strong attractant of gut hematopoietic cells thus promoting the formation Peyer's patch-like structures, a major component of the gut-associated lymphoid tissue. {ECO:0000269|PubMed:10583383, ECO:0000269|PubMed:9883723}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Peyers patch morphogenesis
lymphocyte migration into lymphoid organs
mucosal-associated lymphoid tissue development
Peyers patch development
induction of positive chemotaxis
positive regulation of positive chemotaxis
regulation of positive chemotaxis
neuroblast proliferation
stem cell proliferation
lymphocyte migration
peripheral nervous system development
neural precursor cell proliferation
positive regulation of chemotaxis
growth factor activity
regulation of chemotaxis
axon guidance
neuron projection guidance
signaling receptor binding
axonogenesis
MAPK cascade
leukocyte migration
signal transduction by protein phosphorylation
axon development
cell morphogenesis involved in neuron differentiation
neuron projection morphogenesis
plasma membrane bounded cell projection morphogenesis
cell projection morphogenesis
cell part morphogenesis
chemotaxis
positive regulation of locomotion
taxis
cell population proliferation
cell morphogenesis involved in differentiation
tissue morphogenesis
positive regulation of response to external stimulus
hematopoietic or lymphoid organ development
immune system development
neuron projection development
cell morphogenesis
neuron development