ASAH2

Entrez Summary: N/A
UniProt Summary: Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid at an optimal pH of 6.5-8.5. Acts as a key regulator of sphingolipid signaling metabolites by generating sphingosine at the cell surface. Acts as a repressor of apoptosis both by reducing C16-ceramide, thereby preventing ceramide-induced apoptosis, and generating sphingosine, a precursor of the antiapoptotic factor sphingosine 1-phosphate. Probably involved in the digestion of dietary sphingolipids in intestine by acting as a key enzyme for the catabolism of dietary sphingolipids and regulating the levels of bioactive sphingolipid metabolites in the intestinal tract. {ECO:0000269|PubMed:15946935, ECO:0000269|PubMed:16061940}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

ceramidase activity
N-acylsphingosine amidohydrolase activity
sphingosine biosynthetic process
sphingoid biosynthetic process
sphingosine metabolic process
lipid digestion
sphingoid metabolic process
diol biosynthetic process
ceramide catabolic process
diol metabolic process
long-chain fatty acid biosynthetic process
sphingolipid catabolic process
membrane lipid catabolic process
ceramide biosynthetic process
polyol biosynthetic process
caveola
ceramide metabolic process
sphingolipid biosynthetic process
polyol metabolic process
digestion
alcohol biosynthetic process
long-chain fatty acid metabolic process
fatty acid biosynthetic process
membrane lipid biosynthetic process
sphingolipid metabolic process
organic hydroxy compound biosynthetic process
monocarboxylic acid biosynthetic process
ammonium ion metabolic process
cellular lipid catabolic process
membrane lipid metabolic process
membrane raft
negative regulation of apoptotic signaling pathway
lipid catabolic process
carboxylic acid biosynthetic process
organic acid biosynthetic process
alcohol metabolic process
fatty acid metabolic process
regulation of apoptotic signaling pathway
organic hydroxy compound metabolic process
amide biosynthetic process