ASB1

Entrez Summary: N/A
UniProt Summary: May play a role in testis development (By similarity). Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. {ECO:0000250, ECO:0000269|PubMed:16325183}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

male genitalia development
negative regulation of cytokine biosynthetic process
genitalia development
ubiquitin ligase complex
regulation of cytokine biosynthetic process
male sex differentiation
ubiquitin protein ligase activity
sex differentiation
negative regulation of cytokine production
post-translational protein modification
reproductive structure development
reproductive system development
developmental process involved in reproduction
protein ubiquitination
regulation of cytokine production
protein modification by small protein conjugation
protein modification by small protein conjugation or removal
negative regulation of protein metabolic process
negative regulation of multicellular organismal process
reproductive process
reproduction
negative regulation of macromolecule biosynthetic process
negative regulation of cellular biosynthetic process
negative regulation of biosynthetic process
intracellular signal transduction