ASMT

Entrez Summary: This gene belongs to the methyltransferase superfamily, and is located in the pseudoautosomal region (PAR) at the end of the short arms of the X and Y chromosomes. The encoded enzyme catalyzes the final reaction in the synthesis of melatonin, and is abundant in the pineal gland. Alternatively spliced transcript variants have been noted for this gene. [provided by RefSeq, Jan 2010].
UniProt Summary: Isoform 1 catalyzes the transfer of a methyl group onto N-acetylserotonin, producing melatonin (N-acetyl-5- methoxytryptamine). Isoform 2 and isoform 3 lack enzyme activity. {ECO:0000269|PubMed:22775292}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/694

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/26
bone	0/26
breast	0/30
central nervous system	0/49
cervix	0/4
colorectal	0/17
esophagus	0/11
fibroblast	0/1
gastric	0/14
kidney	0/18
liver	0/19
lung	0/72
lymphocyte	0/16
ovary	0/25
pancreas	0/22
peripheral nervous system	0/15
plasma cell	0/12
prostate	0/1
skin	0/20
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/28
uterus	0/5

Expression Distribution

S-methyltransferase activity
acetylserotonin O-methyltransferase activity
melatonin metabolic process
melatonin biosynthetic process
indole-containing compound biosynthetic process
indolalkylamine biosynthetic process
O-methyltransferase activity
S-adenosylmethionine-dependent methyltransferase activity
indolalkylamine metabolic process
cellular biogenic amine biosynthetic process
indole-containing compound metabolic process
amine biosynthetic process
cellular biogenic amine metabolic process
cellular amine metabolic process
hormone biosynthetic process
amine metabolic process
cellular hormone metabolic process
hormone metabolic process
methylation
translation
peptide biosynthetic process
drug metabolic process
amide biosynthetic process
peptide metabolic process
regulation of hormone levels
cellular amide metabolic process
protein homodimerization activity
identical protein binding
heterocycle biosynthetic process
aromatic compound biosynthetic process
organic cyclic compound biosynthetic process
organonitrogen compound biosynthetic process
cellular nitrogen compound biosynthetic process
cellular macromolecule biosynthetic process
macromolecule biosynthetic process
gene expression