ASTN2

Entrez Summary: This gene encodes a protein that is expressed in the brain and may function in neuronal migration, based on functional studies of the related astrotactin 1 gene in human and mouse. A deletion at this locus has been associated with schizophrenia. Multiple transcript variants encoding different proteins have been found for this locus. [provided by RefSeq, May 2010].
UniProt Summary: N/A

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 1/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	1/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

cell pole
establishment of body hair or bristle planar orientation
establishment of body hair planar orientation
inositol 1,3,4,5 tetrakisphosphate binding
negative regulation of protein localization to cell surface
establishment of tissue polarity
establishment of planar polarity
regulation of protein localization to cell surface
morphogenesis of a polarized epithelium
clathrin-coated vesicle
negative regulation of cellular protein localization
late endosome
perikaryon
cell cortex
early endosome
morphogenesis of an epithelium
regulation of cellular protein localization
tissue morphogenesis
calcium ion binding
regulation of cellular localization
regulation of protein localization
epithelium development
protein transport
peptide transport
amide transport
establishment of protein localization
tissue development
nitrogen compound transport