ATAD1 [The Human Chemical-Genetic Interaction Map Project]

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======= ATAD1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ATAD1
  * **<color #00a2e8>Official Name</color>**: ATPase family AAA domain containing 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=84896|84896]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8NBU5|Q8NBU5]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ATAD1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ATAD1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/614452|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  ATPase that plays a critical role in regulating the surface expression of AMPA receptors (AMPAR), thereby regulating synaptic plasticity and learning and memory. Required for NMDA- stimulated AMPAR internalization and inhibition of GRIA1 and GRIA2 recycling back to the plasma membrane; these activities are ATPase-dependent (By similarity). {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|AAA|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of synaptic transmission, glutamatergic|
|positive regulation of receptor internalization|
|positive regulation of receptor-mediated endocytosis|
|regulation of receptor internalization|
|peroxisomal membrane|
|negative regulation of synaptic transmission|
|regulation of synaptic transmission, glutamatergic|
|positive regulation of endocytosis|
|regulation of receptor-mediated endocytosis|
|memory|
|learning|
|postsynaptic membrane|
|regulation of endocytosis|
|ATPase activity|
|learning or memory|
|cognition|
|modulation of chemical synaptic transmission|
|regulation of trans-synaptic signaling|
|cell junction|
|regulation of vesicle-mediated transport|
|behavior|
|positive regulation of transport|
|positive regulation of cellular component organization|
|negative regulation of cell communication|
|negative regulation of signaling|
|nervous system process|
|ATP binding|
|regulation of transport|
|system process|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp211|AICAR 240μM R05 exp211]]|1.71|
|[[:results:exp199|Etoposide 0.3μM R05 exp199]]|1.73|
|[[:results:exp2|5-Fluorouracil 20μM R00 exp2]]|1.79|
|[[:results:exp440|Aphidicolin 0.4μM R08 exp440]]|1.79|
|[[:results:exp520|Rucaparib 6.5μM R08 exp520]]|1.89|
|[[:results:exp19|Etoposide 1μM R00 exp19]]|2.02|
|[[:results:exp489|Hippuristanol 0.12μM R08 exp489 no dilution day6]]|2.35|
|[[:results:exp512|Olaparib 4μM R08 exp512]]|2.44|
|[[:results:exp85|UM0129480 7μM R02 exp85]]|2.49|
|[[:results:exp135|MS023 7μM R03 exp135]]|2.69|
|[[:results:exp3|Actinomycin-D 0.001μM R00 exp3]]|3.09|
|[[:results:exp488|Hippuristanol 0.12μM R08 exp488]]|3.26|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:a:apaf1|APAF1]]|0.575|
|[[:human genes:v:vdac2|VDAC2]]|0.57|
|[[:human genes:b:bak1|BAK1]]|0.569|
|[[:human genes:d:diablo|DIABLO]]|0.565|
|[[:human genes:m:march5|MARCH5]]|0.559|
|[[:human genes:u:ubqln1|UBQLN1]]|0.538|
|[[:human genes:p:plaa|PLAA]]|0.537|
|[[:human genes:c:casp9|CASP9]]|0.524|
|[[:human genes:f:faf2|FAF2]]|0.501|
|[[:human genes:s:serf2|SERF2]]|0.499|
|[[:human genes:c:cycs|CYCS]]|0.485|
|[[:human genes:m:mfn1|MFN1]]|0.451|
|[[:human genes:g:gabpa|GABPA]]|0.446|
|[[:human genes:h:hccs|HCCS]]|0.427|
|[[:human genes:d:dohh|DOHH]]|0.426|
|[[:human genes:r:romo1|ROMO1]]|0.425|
|[[:human genes:h:hspd1|HSPD1]]|0.419|
|[[:human genes:e:eny2|ENY2]]|0.407|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 10152
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.49 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ATAD1 Expression in NALM6 Cells: 6.49'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>