ATF6 [The Human Chemical-Genetic Interaction Map Project]

This page is read only. You can view the source, but not change it. Ask your administrator if you think this is wrong.
======= ATF6 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ATF6
  * **<color #00a2e8>Official Name</color>**: activating transcription factor 6
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=22926|22926]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P18850|P18850]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ATF6&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ATF6|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605537|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a transcription factor that activates target genes for the unfolded protein response (UPR) during endoplasmic reticulum (ER) stress. Although it is a transcription factor, this protein is unusual in that it is synthesized as a transmembrane protein that is embedded in the ER. It functions as an ER stress sensor/transducer, and following ER stress-induced proteolysis, it functions as a nuclear transcription factor via a cis-acting ER stress response element (ERSE) that is present in the promoters of genes encoding ER chaperones. This protein has been identified as a survival factor for quiescent but not proliferative squamous carcinoma cells. There have been conflicting reports about the association of polymorphisms in this gene with diabetes in different populations, but another polymorphism has been associated with increased plasma cholesterol levels. This gene is also thought to be a potential therapeutic target for cystic fibrosis. [provided by RefSeq, Aug 2011]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Transmembrane glycoprotein of the endoplasmic reticulum that functions as a transcription activator and initiates the unfolded protein response (UPR) during endoplasmic reticulum stress. Cleaved upon ER stress, the N-terminal processed cyclic AMP-dependent transcription factor ATF-6 alpha translocates to the nucleus where it activates transcription of genes involved in the UPR. Binds DNA on the 5'-CCAC[GA]-3'half of the ER stress response element (ERSE) (5'-CCAAT-N(9)-CCAC[GA]-3') and of ERSE II (5'- ATTGG-N-CCACG-3'). Binding to ERSE requires binding of NF-Y to ERSE. Could also be involved in activation of transcription by the serum response factor. May play a role in foveal development and cone function in the retina. {ECO:0000269|PubMed:10564271, ECO:0000269|PubMed:11158310, ECO:0000269|PubMed:11779464, ECO:0000269|PubMed:26029869}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|bZIP 1|
|bZIP 2|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of ATF6-mediated unfolded protein response|
|regulation of ATF6-mediated unfolded protein response|
|ATF6-mediated unfolded protein response|
|positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress|
|positive regulation of endoplasmic reticulum unfolded protein response|
|cAMP response element binding|
|regulation of endoplasmic reticulum unfolded protein response|
|positive regulation of transcription from RNA polymerase II promoter in response to stress|
|ER-nucleus signaling pathway|
|positive regulation of response to endoplasmic reticulum stress|
|transcription regulatory region sequence-specific DNA binding|
|regulation of response to endoplasmic reticulum stress|
|endoplasmic reticulum unfolded protein response|
|integral component of endoplasmic reticulum membrane|
|regulation of transcription from RNA polymerase II promoter in response to stress|
|regulation of DNA-templated transcription in response to stress|
|cellular response to unfolded protein|
|cellular response to topologically incorrect protein|
|response to unfolded protein|
|nuclear envelope|
|response to topologically incorrect protein|
|visual perception|
|sensory perception of light stimulus|
|protein folding|
|response to endoplasmic reticulum stress|
|transcription coactivator activity|
|ubiquitin protein ligase binding|
|RNA polymerase II regulatory region sequence-specific DNA binding|
|eye development|
|visual system development|
|sensory system development|
|sequence-specific DNA binding|
|DNA-binding transcription activator activity, RNA polymerase II-specific|
|protein heterodimerization activity|
|RNA polymerase II proximal promoter sequence-specific DNA binding|
|sensory organ development|
|Golgi membrane|
|positive regulation of apoptotic process|
|positive regulation of programmed cell death|
|DNA-binding transcription factor activity|
|positive regulation of cell death|
|regulation of cellular response to stress|
|endoplasmic reticulum membrane|
|sensory perception|
|Golgi apparatus|
|endoplasmic reticulum|
|identical protein binding|
|positive regulation of transcription by RNA polymerase II|
|nervous system process|
|regulation of response to stress|
|positive regulation of transcription, DNA-templated|
|regulation of apoptotic process|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|regulation of programmed cell death|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|positive regulation of signal transduction|
|regulation of cell death|
|cellular response to stress|
|positive regulation of RNA metabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|system process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|membrane|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp78|Pterostilbene 16μM R02 exp78]]|-1.74|
|[[:results:exp497|Lead acetate 2000μM R08 exp497]]|-1.7|
|[[:results:exp3|Actinomycin-D 0.001μM R00 exp3]]|1.7|
|[[:results:exp18|Doxycycline 10μM R00 exp18]]|1.73|
|[[:results:exp129|Isonicotinamide 500μM R03 exp129]]|1.78|
|[[:results:exp19|Etoposide 1μM R00 exp19]]|1.79|
|[[:results:exp508|NN-Dimethylsphingosine 2.5μM R08 exp508]]|1.81|
|[[:results:exp10|CCCP 0.1μM R00 exp10]]|1.83|
|[[:results:exp125|GSK461364A 0.005μM R03 exp125]]|1.84|
|[[:results:exp380|NMS-873 0.07μM R07 exp380]]|1.85|
|[[:results:exp106|UM131593 0.2μM R03 exp106]]|1.86|
|[[:results:exp5|Alpha-Amanitin 0.5μM R00 exp5]]|1.88|
|[[:results:exp343|Centrinone 0.5μM R07 exp343]]|1.93|
|[[:results:exp23|Nocodazole 0.02μM R00 exp23]]|1.94|
|[[:results:exp73|LJH685 5μM R02 exp73]]|2.01|
|[[:results:exp130|JQ1 0.01μM R03 exp130]]|2.09|
|[[:results:exp185|L-BMAA 500 to 750μM on day4 R04 exp185]]|2.18|
|[[:results:exp11|CCCP 1μM R00 exp11]]|2.21|
|[[:results:exp12|Chloramphenicol 2μM R00 exp12]]|2.54|
|[[:results:exp103|Taxol 0.004μM R03 exp103]]|2.75|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2388
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.43 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ATF6 Expression in NALM6 Cells: 6.43'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>