ATF6

Gene Information

Official Symbol: ATF6
Official Name: activating transcription factor 6
Aliases and Previous Symbols: N/A
Entrez ID: 22926
UniProt: P18850
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene encodes a transcription factor that activates target genes for the unfolded protein response (UPR) during endoplasmic reticulum (ER) stress. Although it is a transcription factor, this protein is unusual in that it is synthesized as a transmembrane protein that is embedded in the ER. It functions as an ER stress sensor/transducer, and following ER stress-induced proteolysis, it functions as a nuclear transcription factor via a cis-acting ER stress response element (ERSE) that is present in the promoters of genes encoding ER chaperones. This protein has been identified as a survival factor for quiescent but not proliferative squamous carcinoma cells. There have been conflicting reports about the association of polymorphisms in this gene with diabetes in different populations, but another polymorphism has been associated with increased plasma cholesterol levels. This gene is also thought to be a potential therapeutic target for cystic fibrosis. [provided by RefSeq, Aug 2011].
UniProt Summary: Transmembrane glycoprotein of the endoplasmic reticulum that functions as a transcription activator and initiates the unfolded protein response (UPR) during endoplasmic reticulum stress. Cleaved upon ER stress, the N-terminal processed cyclic AMP-dependent transcription factor ATF-6 alpha translocates to the nucleus where it activates transcription of genes involved in the UPR. Binds DNA on the 5'-CCAC[GA]-3'half of the ER stress response element (ERSE) (5'-CCAAT-N(9)-CCAC[GA]-3') and of ERSE II (5'- ATTGG-N-CCACG-3'). Binding to ERSE requires binding of NF-Y to ERSE. Could also be involved in activation of transcription by the serum response factor. May play a role in foveal development and cone function in the retina. {ECO:0000269|PubMed:10564271, ECO:0000269|PubMed:11158310, ECO:0000269|PubMed:11779464, ECO:0000269|PubMed:26029869}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Pterostilbene 16μM R02 exp78	-1.74
Lead acetate 2000μM R08 exp497	-1.7
Actinomycin-D 0.001μM R00 exp3	1.7
Doxycycline 10μM R00 exp18	1.73
Isonicotinamide 500μM R03 exp129	1.78
Etoposide 1μM R00 exp19	1.79
NN-Dimethylsphingosine 2.5μM R08 exp508	1.81
CCCP 0.1μM R00 exp10	1.83
GSK461364A 0.005μM R03 exp125	1.84
NMS-873 0.07μM R07 exp380	1.85
UM131593 0.2μM R03 exp106	1.86
Alpha-Amanitin 0.5μM R00 exp5	1.88
Centrinone 0.5μM R07 exp343	1.93
Nocodazole 0.02μM R00 exp23	1.94
LJH685 5μM R02 exp73	2.01
JQ1 0.01μM R03 exp130	2.09
L-BMAA 500 to 750μM on day4 R04 exp185	2.18
CCCP 1μM R00 exp11	2.21
Chloramphenicol 2μM R00 exp12	2.54
Taxol 0.004μM R03 exp103	2.75

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 2388
Expression level (log2 read counts): 6.43

Expression Distribution

bZIP 1
bZIP 2

positive regulation of ATF6-mediated unfolded protein response
regulation of ATF6-mediated unfolded protein response
ATF6-mediated unfolded protein response
positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress
positive regulation of endoplasmic reticulum unfolded protein response
cAMP response element binding
regulation of endoplasmic reticulum unfolded protein response
positive regulation of transcription from RNA polymerase II promoter in response to stress
ER-nucleus signaling pathway
positive regulation of response to endoplasmic reticulum stress
transcription regulatory region sequence-specific DNA binding
regulation of response to endoplasmic reticulum stress
endoplasmic reticulum unfolded protein response
integral component of endoplasmic reticulum membrane
regulation of transcription from RNA polymerase II promoter in response to stress
regulation of DNA-templated transcription in response to stress
cellular response to unfolded protein
cellular response to topologically incorrect protein
response to unfolded protein
nuclear envelope
response to topologically incorrect protein
visual perception
sensory perception of light stimulus
protein folding
response to endoplasmic reticulum stress
transcription coactivator activity
ubiquitin protein ligase binding
RNA polymerase II regulatory region sequence-specific DNA binding
eye development
visual system development
sensory system development
sequence-specific DNA binding
DNA-binding transcription activator activity, RNA polymerase II-specific
protein heterodimerization activity
RNA polymerase II proximal promoter sequence-specific DNA binding
sensory organ development
Golgi membrane
positive regulation of apoptotic process
positive regulation of programmed cell death
DNA-binding transcription factor activity