ATF6B

Gene Information

Official Symbol: ATF6B
Official Name: activating transcription factor 6 beta
Aliases and Previous Symbols: N/A
Entrez ID: 1388
UniProt: Q99941
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: The protein encoded by this gene is a transcription factor in the unfolded protein response (UPR) pathway during ER stress. Either as a homodimer or as a heterodimer with ATF6-alpha, the encoded protein binds to the ER stress response element, interacting with nuclear transcription factor Y to activate UPR target genes. The protein is normally found in the membrane of the endoplasmic reticulum; however, under ER stress, the N-terminal cytoplasmic domain is cleaved from the rest of the protein and translocates to the nucleus. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008].
UniProt Summary: N/A

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 12901
Expression level (log2 read counts): 7.12

Expression Distribution

Screen	Score
Vinorelbine 0.001μM R05 exp249	-1.73
Zebularine 20μM R07 exp423	1.77

bZIP 2
bZIP 1

negative regulation of ATF6-mediated unfolded protein response
regulation of ATF6-mediated unfolded protein response
ATF6-mediated unfolded protein response
negative regulation of endoplasmic reticulum unfolded protein response
positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress
cAMP response element binding
regulation of endoplasmic reticulum unfolded protein response
positive regulation of transcription from RNA polymerase II promoter in response to stress
ER-nucleus signaling pathway
negative regulation of response to endoplasmic reticulum stress
protein-DNA complex
RNA polymerase II transcription factor complex
regulation of response to endoplasmic reticulum stress
RNA polymerase II distal enhancer sequence-specific DNA binding
endoplasmic reticulum unfolded protein response
integral component of endoplasmic reticulum membrane
regulation of transcription from RNA polymerase II promoter in response to stress
regulation of DNA-templated transcription in response to stress
cellular response to unfolded protein
cellular response to topologically incorrect protein
response to unfolded protein
response to topologically incorrect protein
transcription regulatory region DNA binding
response to endoplasmic reticulum stress
DNA-binding transcription activator activity, RNA polymerase II-specific
transcription, DNA-templated
nucleic acid-templated transcription
RNA biosynthetic process
DNA-binding transcription factor activity
regulation of cellular response to stress
nucleolus
endoplasmic reticulum membrane
Golgi apparatus
nucleobase-containing compound biosynthetic process
heterocycle biosynthetic process
aromatic compound biosynthetic process
positive regulation of transcription by RNA polymerase II
negative regulation of signal transduction
organic cyclic compound biosynthetic process
negative regulation of cell communication