ATG10 [The Human Chemical-Genetic Interaction Map Project]

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======= ATG10 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ATG10
  * **<color #00a2e8>Official Name</color>**: autophagy related 10
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=83734|83734]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9H0Y0|Q9H0Y0]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ATG10&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ATG10|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/610800|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  E2-like enzyme involved in autophagy. Acts as an E2-like enzyme that catalyzes the conjugation of ATG12 to ATG5. ATG12 conjugation to ATG5 is required for autophagy. Likely serves as an ATG5-recognition molecule. Not involved in ATG12 conjugation to ATG3 (By similarity). Plays a role in adenovirus-mediated cell lysis. {ECO:0000250, ECO:0000269|PubMed:21367888}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Autophagy act C|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|Atg12 transferase activity|
|ER overload response|
|ER-nucleus signaling pathway|
|protein lipidation|
|intracellular|
|lipoprotein biosynthetic process|
|lipoprotein metabolic process|
|macroautophagy|
|cellular response to biotic stimulus|
|response to endoplasmic reticulum stress|
|process utilizing autophagic mechanism|
|autophagy|
|protein modification by small protein conjugation|
|protein modification by small protein conjugation or removal|
|positive regulation of protein modification process|
|response to biotic stimulus|
|organonitrogen compound biosynthetic process|
|protein transport|
|peptide transport|
|amide transport|
|positive regulation of cellular protein metabolic process|
|establishment of protein localization|
|cellular response to stress|
|positive regulation of protein metabolic process|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
|cellular catabolic process|
|regulation of protein modification process|
|nitrogen compound transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp488|Hippuristanol 0.12μM R08 exp488]]|1.73|
|[[:results:exp490|Hydroxychloroquine 30μM R08 exp490]]|1.77|
|[[:results:exp452|Azithromycin 100μM R08 exp452]]|1.78|
|[[:results:exp21|MLN-4924 0.2μM R00 exp21]]|1.81|
|[[:results:exp164|Q15 1 to 2μM on day4 R04 exp164]]|1.82|
|[[:results:exp496|Lead acetate 990μM R08 exp496]]|2.31|
|[[:results:exp539|42°C R08 exp539]]|2.41|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 16748
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.36 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ATG10 Expression in NALM6 Cells: 5.36'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>