ATG10

Entrez Summary: N/A
UniProt Summary: E2-like enzyme involved in autophagy. Acts as an E2-like enzyme that catalyzes the conjugation of ATG12 to ATG5. ATG12 conjugation to ATG5 is required for autophagy. Likely serves as an ATG5-recognition molecule. Not involved in ATG12 conjugation to ATG3 (By similarity). Plays a role in adenovirus-mediated cell lysis. {ECO:0000250, ECO:0000269|PubMed:21367888}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Atg12 transferase activity
ER overload response
ER-nucleus signaling pathway
protein lipidation
intracellular
lipoprotein biosynthetic process
lipoprotein metabolic process
macroautophagy
cellular response to biotic stimulus
response to endoplasmic reticulum stress
process utilizing autophagic mechanism
autophagy
protein modification by small protein conjugation
protein modification by small protein conjugation or removal
positive regulation of protein modification process
response to biotic stimulus
organonitrogen compound biosynthetic process
protein transport
peptide transport
amide transport
positive regulation of cellular protein metabolic process
establishment of protein localization
cellular response to stress
positive regulation of protein metabolic process
cellular macromolecule biosynthetic process
macromolecule biosynthetic process
cellular catabolic process
regulation of protein modification process
nitrogen compound transport