ATIC [The Human Chemical-Genetic Interaction Map Project]

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======= ATIC =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ATIC
  * **<color #00a2e8>Official Name</color>**: 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=471|471]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P31939|P31939]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ATIC&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ATIC|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/601731|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a bifunctional protein that catalyzes the last two steps of the de novo purine biosynthetic pathway. The N-terminal domain has phosphoribosylaminoimidazolecarboxamide formyltransferase activity, and the C-terminal domain has IMP cyclohydrolase activity. A mutation in this gene results in AICA-ribosiduria. [provided by RefSeq, Sep 2009]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Bifunctional enzyme that catalyzes 2 steps in purine biosynthesis. {ECO:0000269|PubMed:14966129}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|MGS|
|AICARFT IMPCHas|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|IMP cyclohydrolase activity|
|phosphoribosylaminoimidazolecarboxamide formyltransferase activity|
|dihydrofolate metabolic process|
|de novo IMP biosynthetic process|
|brainstem development|
|tetrahydrofolate biosynthetic process|
|IMP biosynthetic process|
|folic acid-containing compound biosynthetic process|
|IMP metabolic process|
|pteridine-containing compound biosynthetic process|
|purine nucleoside monophosphate biosynthetic process|
|tetrahydrofolate metabolic process|
|purine ribonucleoside monophosphate biosynthetic process|
|response to interleukin-7|
|cellular response to interleukin-7|
|folic acid-containing compound metabolic process|
|ribonucleoside monophosphate biosynthetic process|
|pteridine-containing compound metabolic process|
|purine ribonucleoside monophosphate metabolic process|
|purine nucleoside monophosphate metabolic process|
|nucleoside monophosphate biosynthetic process|
|cellular modified amino acid biosynthetic process|
|ribonucleoside monophosphate metabolic process|
|nucleoside monophosphate metabolic process|
|animal organ regeneration|
|dicarboxylic acid metabolic process|
|cerebellum development|
|nucleoside metabolic process|
|metencephalon development|
|cerebral cortex development|
|glycosyl compound metabolic process|
|coenzyme biosynthetic process|
|purine ribonucleotide biosynthetic process|
|hindbrain development|
|purine nucleotide biosynthetic process|
|regeneration|
|ribonucleotide biosynthetic process|
|ribose phosphate biosynthetic process|
|purine-containing compound biosynthetic process|
|pallium development|
|cellular modified amino acid metabolic process|
|cofactor biosynthetic process|
|nucleotide biosynthetic process|
|nucleoside phosphate biosynthetic process|
|coenzyme metabolic process|
|telencephalon development|
|carboxylic acid biosynthetic process|
|organic acid biosynthetic process|
|cadherin binding|
|purine ribonucleotide metabolic process|
|ribonucleotide metabolic process|
|purine nucleotide metabolic process|
|ribose phosphate metabolic process|
|purine-containing compound metabolic process|
|forebrain development|
|cofactor metabolic process|
|nucleotide metabolic process|
|nucleoside phosphate metabolic process|
|amide biosynthetic process|
|response to inorganic substance|
|organophosphate biosynthetic process|
|nucleobase-containing small molecule metabolic process|
|small molecule biosynthetic process|
|carbohydrate derivative biosynthetic process|
|brain development|
|head development|
|cellular amide metabolic process|
|protein homodimerization activity|
|organophosphate metabolic process|
|carboxylic acid metabolic process|
|central nervous system development|
|oxoacid metabolic process|
|cellular response to cytokine stimulus|
|organic acid metabolic process|
|carbohydrate derivative metabolic process|
|nucleobase-containing compound biosynthetic process|
|response to cytokine|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|organic cyclic compound biosynthetic process|
|organonitrogen compound biosynthetic process|
|cellular nitrogen compound biosynthetic process|
|small molecule metabolic process|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp493|IL-3 9ng/ml R08 exp493]]|-2.62|
|[[:results:exp75|MK-1775 0.32μM R02 exp75]]|-2.4|
|[[:results:exp501|Methotrexate 0.01μM R08 exp501]]|-2.2|
|[[:results:exp500|LY2090314 0.003μM R08 exp500 no dilution day6]]|-2.19|
|[[:results:exp486|Heregulin-B 44ng/ml R08 exp486]]|-2.15|
|[[:results:exp477|DKK1 89ng/ml R08 exp477]]|-2.12|
|[[:results:exp272|CHIR-124 0.04μM R06 exp272]]|-2.09|
|[[:results:exp190|Vincristine 0.0005μM R04 exp190]]|-2.03|
|[[:results:exp185|L-BMAA 500 to 750μM on day4 R04 exp185]]|-2.01|
|[[:results:exp239|PFI-2 4μM R05 exp239]]|-2|
|[[:results:exp484|GSK-J5 1.5μM R08 exp484]]|-1.98|
|[[:results:exp243|S-trityl-L-cysteine 0.5μM R05 exp243]]|-1.98|
|[[:results:exp410|THZ531 0.11 to 0.125μM on day4 R07 exp410]]|-1.96|
|[[:results:exp124|GSK343 3μM R03 exp124]]|-1.93|
|[[:results:exp510|Nicotine 3000μM R08 exp510]]|-1.87|
|[[:results:exp482|Fas-L 44ng/ml R08 exp482]]|-1.86|
|[[:results:exp332|Adefovir 20μM R07 exp332]]|-1.86|
|[[:results:exp285|GW501516 25μM R06 exp285]]|-1.85|
|[[:results:exp286|HMS-I2 1μM R06 exp286]]|-1.84|
|[[:results:exp464|Calcipotriol 5μM R08 exp464]]|-1.82|
|[[:results:exp170|Metformin 100 to 150μM on day4 R04 exp170]]|-1.81|
|[[:results:exp314|Dimethyloxaloylglycine 11μM R07 exp314]]|-1.74|
|[[:results:exp11|CCCP 1μM R00 exp11]]|-1.72|
|[[:results:exp141|Nifurtimox 1μM R03 exp141]]|-1.71|
|[[:results:exp182|IU1-47 25μM R04 exp182]]|-1.7|
|[[:results:exp256|HMS-I1 10μM R06 exp256]]|1.7|
|[[:results:exp447|Amiloride 100μM R08 exp447]]|1.72|
|[[:results:exp472|CI-1040 9.5μM R08 exp472]]|1.72|
|[[:results:exp33|Rotenone 2μM R00 exp33]]|1.76|
|[[:results:exp527|Tanespimycin 14μM R08 exp527]]|1.78|
|[[:results:exp126|GSK461364A 0.1μM R03 exp126]]|1.83|
|[[:results:exp22|MLN-4924 2μM R00 exp22]]|1.84|
|[[:results:exp374|Latrunculin-B 10μM R07 exp374]]|1.86|
|[[:results:exp503|Mitomycin-C 0.06μM R08 exp503]]|1.87|
|[[:results:exp469|CFI-400945 25μM R08 exp469]]|1.89|
|[[:results:exp532|TIC10 10μM R08 exp532]]|1.89|
|[[:results:exp90|WYE-354 6μM R02 exp90]]|1.91|
|[[:results:exp98|BI-6727 0.04μM R03 exp98]]|1.93|
|[[:results:exp515|PU-H71 1μM R08 exp515]]|2|
|[[:results:exp468|CB-5083 0.4μM R08 exp468]]|2.12|
|[[:results:exp360|Genistein 15μM R07 exp360]]|2.16|
|[[:results:exp96|BI-2536 0.02μM R03 exp96]]|2.2|
|[[:results:exp82|Torin1 0.08μM R02 exp82]]|2.22|
|[[:results:exp443|SNS-032 15μM R08 exp443]]|2.27|
|[[:results:exp414|Tozasertib 0.1μM R07 exp414]]|2.33|
|[[:results:exp492|iCRT14 30μM R08 exp492]]|2.52|
|[[:results:exp487|Hinokiflavone 12μM R08 exp487]]|2.54|
|[[:results:exp350|Deferoxamine 11μM R07 exp350]]|2.58|
|[[:results:exp504|MK2206 4μM R08 exp504]]|2.62|
|[[:results:exp135|MS023 7μM R03 exp135]]|2.67|
|[[:results:exp355|Dinaciclib 0.007μM R07 exp355]]|2.68|
|[[:results:exp116|AICAR 240μM R03 exp116]]|2.75|
|[[:results:exp214|2-Deoxy-D-glucose 800μM R05 exp214]]|3.18|
|[[:results:exp435|JQ1 0.8μM R08 exp435]]|3.3|
|[[:results:exp450|Artemisinin 50μM R08 exp450]]|3.36|
|[[:results:exp211|AICAR 240μM R05 exp211]]|3.38|
|[[:results:exp382|Palbociclib 1μM R07 exp382]]|3.41|
|[[:results:exp502|Milciclib 2μM R08 exp502]]|3.56|
|[[:results:exp475|CyclicAMP 200μM R08 exp475]]|3.58|
|[[:results:exp134|MS023 2μM R03 exp134]]|4.07|
|[[:results:exp227|Cryptotanshinone 12μM R05 exp227]]|4.9|
|[[:results:exp84|UM0125461 0.74μM R02 exp84]]|4.91|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:t:thg1l|THG1L]]|0.634|
|[[:human genes:v:vezt|VEZT]]|0.611|
|[[:human genes:a:atxn10|ATXN10]]|0.572|
|[[:human genes:a:aasdhppt|AASDHPPT]]|0.567|
|[[:human genes:s:slc25a26|SLC25A26]]|0.564|
|[[:human genes:f:fh|FH]]|0.552|
|[[:human genes:s:slc25a19|SLC25A19]]|0.548|
|[[:human genes:r:rpia|RPIA]]|0.546|
|[[:human genes:g:gemin6|GEMIN6]]|0.538|
|[[:human genes:u:urm1|URM1]]|0.535|
|[[:human genes:t:triap1|TRIAP1]]|0.532|
|[[:human genes:g:gemin8|GEMIN8]]|0.53|
|[[:human genes:d:dpagt1|DPAGT1]]|0.524|
|[[:human genes:p:ppcs|PPCS]]|0.52|
|[[:human genes:e:elp3|ELP3]]|0.52|
|[[:human genes:b:bcs1l|BCS1L]]|0.516|
|[[:human genes:s:srp14|SRP14]]|0.514|
|[[:human genes:t:tpk1|TPK1]]|0.509|
|[[:human genes:p:pgm3|PGM3]]|0.509|
|[[:human genes:e:elp2|ELP2]]|0.506|
|[[:human genes:c:c15orf41|C15orf41]]|0.505|
|[[:human genes:d:dr1|DR1]]|0.503|
|[[:human genes:a:alg1|ALG1]]|0.503|
|[[:human genes:d:dolk|DOLK]]|0.5|
|[[:human genes:r:rpe|RPE]]|0.498|
|[[:human genes:r:rfk|RFK]]|0.495|
|[[:human genes:s:ssb|SSB]]|0.494|
|[[:human genes:u:uap1|UAP1]]|0.493|
|[[:human genes:a:adsl|ADSL]]|0.492|
|[[:human genes:p:pmm2|PMM2]]|0.487|
|[[:human genes:d:dhrsx|DHRSX]]|0.486|
|[[:human genes:d:dars2|DARS2]]|0.486|
|[[:human genes:t:trmt61a|TRMT61A]]|0.486|
|[[:human genes:t:tkt|TKT]]|0.483|
|[[:human genes:h:hsd17b10|HSD17B10]]|0.477|
|[[:human genes:l:lsm10|LSM10]]|0.475|
|[[:human genes:m:mthfd1|MTHFD1]]|0.473|
|[[:human genes:m:mrps14|MRPS14]]|0.472|
|[[:human genes:c:chchd4|CHCHD4]]|0.472|
|[[:human genes:d:dohh|DOHH]]|0.471|
|[[:human genes:r:rft1|RFT1]]|0.47|
|[[:human genes:m:mocs3|MOCS3]]|0.469|
|[[:human genes:k:kdsr|KDSR]]|0.467|
|[[:human genes:d:dnlz|DNLZ]]|0.467|
|[[:human genes:u:uba3|UBA3]]|0.465|
|[[:human genes:g:gmppb|GMPPB]]|0.462|
|[[:human genes:w:wdr92|WDR92]]|0.461|
|[[:human genes:t:ten1|TEN1]]|0.458|
|[[:human genes:r:rabggtb|RABGGTB]]|0.458|
|[[:human genes:t:ttc4|TTC4]]|0.455|
|[[:human genes:p:pyroxd1|PYROXD1]]|0.454|
|[[:human genes:k:kiaa0391|KIAA0391]]|0.453|
|[[:human genes:m:mrps34|MRPS34]]|0.451|
|[[:human genes:s:srd5a3|SRD5A3]]|0.451|
|[[:human genes:d:dap3|DAP3]]|0.447|
|[[:human genes:z:zrsr2|ZRSR2]]|0.447|
|[[:human genes:d:ddx1|DDX1]]|0.446|
|[[:human genes:m:mrps2|MRPS2]]|0.445|
|[[:human genes:c:ctu1|CTU1]]|0.443|
|[[:human genes:m:mrps16|MRPS16]]|0.443|
|[[:human genes:r:romo1|ROMO1]]|0.44|
|[[:human genes:e:elp6|ELP6]]|0.44|
|[[:human genes:z:zcrb1|ZCRB1]]|0.439|
|[[:human genes:s:sco2|SCO2]]|0.438|
|[[:human genes:m:mrpl21|MRPL21]]|0.436|
|[[:human genes:n:nfu1|NFU1]]|0.436|
|[[:human genes:t:tsen54|TSEN54]]|0.433|
|[[:human genes:r:rpp21|RPP21]]|0.433|
|[[:human genes:u:uqcrc2|UQCRC2]]|0.43|
|[[:human genes:r:rtcb|RTCB]]|0.43|
|[[:human genes:r:rbfa|RBFA]]|0.43|
|[[:human genes:t:tubd1|TUBD1]]|0.429|
|[[:human genes:t:tamm41|TAMM41]]|0.429|
|[[:human genes:g:gfpt1|GFPT1]]|0.427|
|[[:human genes:g:gtf3c3|GTF3C3]]|0.427|
|[[:human genes:s:supv3l1|SUPV3L1]]|0.425|
|[[:human genes:n:n6amt1|N6AMT1]]|0.422|
|[[:human genes:m:mrps6|MRPS6]]|0.421|
|[[:human genes:y:yars2|YARS2]]|0.42|
|[[:human genes:s:sars2|SARS2]]|0.42|
|[[:human genes:m:mrpl27|MRPL27]]|0.42|
|[[:human genes:r:rptor|RPTOR]]|0.418|
|[[:human genes:t:trmt5|TRMT5]]|0.418|
|[[:human genes:w:wdr59|WDR59]]|0.417|
|[[:human genes:h:hccs|HCCS]]|0.417|
|[[:human genes:e:elac2|ELAC2]]|0.416|
|[[:human genes:n:nae1|NAE1]]|0.416|
|[[:human genes:t:tmem208|TMEM208]]|0.416|
|[[:human genes:k:kctd5|KCTD5]]|0.413|
|[[:human genes:g:gemin7|GEMIN7]]|0.413|
|[[:human genes:u:uqcr10|UQCR10]]|0.412|
|[[:human genes:p:ppcdc|PPCDC]]|0.412|
|[[:human genes:g:gfm1|GFM1]]|0.412|
|[[:human genes:m:mrps26|MRPS26]]|0.412|
|[[:human genes:p:ppp6c|PPP6C]]|0.411|
|[[:human genes:c:cox16|COX16]]|0.41|
|[[:human genes:d:dhps|DHPS]]|0.41|
|[[:human genes:m:mis18a|MIS18A]]|0.41|
|[[:human genes:u:uhrf1|UHRF1]]|0.41|
|[[:human genes:c:cep57|CEP57]]|0.409|
|[[:human genes:b:bak1|BAK1]]|0.407|
|[[:human genes:o:oraov1|ORAOV1]]|0.407|
|[[:human genes:m:mrps21|MRPS21]]|0.406|
|[[:human genes:r:rad1|RAD1]]|0.404|
|[[:human genes:t:tufm|TUFM]]|0.403|
|[[:human genes:p:ppa1|PPA1]]|0.401|
|[[:human genes:c:c14orf80|C14orf80]]|0.401|
|[[:human genes:d:ddx39a|DDX39A]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 43/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|2/28|
|blood|2/28|
|bone|2/26|
|breast|5/33|
|central nervous system|1/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|1/21|
|liver|0/20|
|lung|6/75|
|lymphocyte|1/16|
|ovary|1/26|
|pancreas|1/24|
|peripheral nervous system|0/16|
|plasma cell|2/15|
|prostate|0/1|
|skin|1/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|3/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 20
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.15 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ATIC Expression in NALM6 Cells: 7.15'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>