ATIC

Gene Information

Official Symbol: ATIC
Official Name: 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase
Aliases and Previous Symbols: N/A
Entrez ID: 471
UniProt: P31939
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene encodes a bifunctional protein that catalyzes the last two steps of the de novo purine biosynthetic pathway. The N-terminal domain has phosphoribosylaminoimidazolecarboxamide formyltransferase activity, and the C-terminal domain has IMP cyclohydrolase activity. A mutation in this gene results in AICA-ribosiduria. [provided by RefSeq, Sep 2009].
UniProt Summary: Bifunctional enzyme that catalyzes 2 steps in purine biosynthesis. {ECO:0000269|PubMed:14966129}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
IL-3 9ng/ml R08 exp493	-2.62
MK-1775 0.32μM R02 exp75	-2.4
Methotrexate 0.01μM R08 exp501	-2.2
LY2090314 0.003μM R08 exp500 no dilution day6	-2.19
Heregulin-B 44ng/ml R08 exp486	-2.15
DKK1 89ng/ml R08 exp477	-2.12
CHIR-124 0.04μM R06 exp272	-2.09
Vincristine 0.0005μM R04 exp190	-2.03
L-BMAA 500 to 750μM on day4 R04 exp185	-2.01
PFI-2 4μM R05 exp239	-2
GSK-J5 1.5μM R08 exp484	-1.98
S-trityl-L-cysteine 0.5μM R05 exp243	-1.98
THZ531 0.11 to 0.125μM on day4 R07 exp410	-1.96
GSK343 3μM R03 exp124	-1.93
Nicotine 3000μM R08 exp510	-1.87
Fas-L 44ng/ml R08 exp482	-1.86
Adefovir 20μM R07 exp332	-1.86
GW501516 25μM R06 exp285	-1.85
HMS-I2 1μM R06 exp286	-1.84
Calcipotriol 5μM R08 exp464	-1.82
Metformin 100 to 150μM on day4 R04 exp170	-1.81
Dimethyloxaloylglycine 11μM R07 exp314	-1.74
CCCP 1μM R00 exp11	-1.72
Nifurtimox 1μM R03 exp141	-1.71
IU1-47 25μM R04 exp182	-1.7
HMS-I1 10μM R06 exp256	1.7
Amiloride 100μM R08 exp447	1.72
CI-1040 9.5μM R08 exp472	1.72
Rotenone 2μM R00 exp33	1.76
Tanespimycin 14μM R08 exp527	1.78
GSK461364A 0.1μM R03 exp126	1.83
MLN-4924 2μM R00 exp22	1.84
Latrunculin-B 10μM R07 exp374	1.86
Mitomycin-C 0.06μM R08 exp503	1.87
CFI-400945 25μM R08 exp469	1.89
TIC10 10μM R08 exp532	1.89
WYE-354 6μM R02 exp90	1.91
BI-6727 0.04μM R03 exp98	1.93
PU-H71 1μM R08 exp515	2
CB-5083 0.4μM R08 exp468	2.12
Genistein 15μM R07 exp360	2.16
BI-2536 0.02μM R03 exp96	2.2
Torin1 0.08μM R02 exp82	2.22
SNS-032 15μM R08 exp443	2.27
Tozasertib 0.1μM R07 exp414	2.33
iCRT14 30μM R08 exp492	2.52
Hinokiflavone 12μM R08 exp487	2.54
Deferoxamine 11μM R07 exp350	2.58
MK2206 4μM R08 exp504	2.62
MS023 7μM R03 exp135	2.67
Dinaciclib 0.007μM R07 exp355	2.68
AICAR 240μM R03 exp116	2.75
2-Deoxy-D-glucose 800μM R05 exp214	3.18
JQ1 0.8μM R08 exp435	3.3
Artemisinin 50μM R08 exp450	3.36
AICAR 240μM R05 exp211	3.38
Palbociclib 1μM R07 exp382	3.41
Milciclib 2μM R08 exp502	3.56
CyclicAMP 200μM R08 exp475	3.58
MS023 2μM R03 exp134	4.07
Cryptotanshinone 12μM R05 exp227	4.9
UM0125461 0.74μM R02 exp84	4.91

Gene	Correlation
THG1L	0.634
VEZT	0.611
ATXN10	0.572
AASDHPPT	0.567
SLC25A26	0.564
FH	0.552
SLC25A19	0.548
RPIA	0.546
GEMIN6	0.538
URM1	0.535
TRIAP1	0.532
GEMIN8	0.53
DPAGT1	0.524
PPCS	0.52
ELP3	0.52
BCS1L	0.516
SRP14	0.514
TPK1	0.509
PGM3	0.509
ELP2	0.506
C15orf41	0.505
DR1	0.503
ALG1	0.503
DOLK	0.5
RPE	0.498
RFK	0.495
SSB	0.494
UAP1	0.493
ADSL	0.492
PMM2	0.487
DHRSX	0.486
DARS2	0.486
TRMT61A	0.486
TKT	0.483
HSD17B10	0.477
LSM10	0.475
MTHFD1	0.473
MRPS14	0.472
CHCHD4	0.472
DOHH	0.471
RFT1	0.47
MOCS3	0.469
KDSR	0.467
DNLZ	0.467
UBA3	0.465
GMPPB	0.462
WDR92	0.461
TEN1	0.458
RABGGTB	0.458
TTC4	0.455
PYROXD1	0.454
KIAA0391	0.453
MRPS34	0.451
SRD5A3	0.451
DAP3	0.447
ZRSR2	0.447
DDX1	0.446
MRPS2	0.445
CTU1	0.443
MRPS16	0.443
ROMO1	0.44
ELP6	0.44
ZCRB1	0.439
SCO2	0.438
MRPL21	0.436
NFU1	0.436
TSEN54	0.433
RPP21	0.433
UQCRC2	0.43
RTCB	0.43
RBFA	0.43
TUBD1	0.429
TAMM41	0.429
GFPT1	0.427
GTF3C3	0.427
SUPV3L1	0.425
N6AMT1	0.422
MRPS6	0.421
YARS2	0.42
SARS2	0.42
MRPL27	0.42
RPTOR	0.418
TRMT5	0.418
WDR59	0.417
HCCS	0.417
ELAC2	0.416
NAE1	0.416
TMEM208	0.416
KCTD5	0.413
GEMIN7	0.413
UQCR10	0.412
PPCDC	0.412
GFM1	0.412
MRPS26	0.412
PPP6C	0.411
COX16	0.41
DHPS	0.41
MIS18A	0.41
UHRF1	0.41
CEP57	0.409
BAK1	0.407
ORAOV1	0.407
MRPS21	0.406
RAD1	0.404
TUFM	0.403
PPA1	0.401
C14orf80	0.401
DDX39A	0.4

Global Fraction of Cell Lines Where Essential: 43/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	2/28
blood	2/28
bone	2/26
breast	5/33
central nervous system	1/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	1/21
liver	0/20
lung	6/75
lymphocyte	1/16
ovary	1/26
pancreas	1/24
peripheral nervous system	0/16
plasma cell	2/15
prostate	0/1
skin	1/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	3/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 20
Expression level (log2 read counts): 7.15

Expression Distribution

MGS
AICARFT IMPCHas

IMP cyclohydrolase activity
phosphoribosylaminoimidazolecarboxamide formyltransferase activity
dihydrofolate metabolic process
de novo IMP biosynthetic process
brainstem development
tetrahydrofolate biosynthetic process
IMP biosynthetic process
folic acid-containing compound biosynthetic process
IMP metabolic process
pteridine-containing compound biosynthetic process
purine nucleoside monophosphate biosynthetic process
tetrahydrofolate metabolic process
purine ribonucleoside monophosphate biosynthetic process
response to interleukin-7
cellular response to interleukin-7
folic acid-containing compound metabolic process
ribonucleoside monophosphate biosynthetic process
pteridine-containing compound metabolic process
purine ribonucleoside monophosphate metabolic process
purine nucleoside monophosphate metabolic process
nucleoside monophosphate biosynthetic process
cellular modified amino acid biosynthetic process
ribonucleoside monophosphate metabolic process
nucleoside monophosphate metabolic process
animal organ regeneration
dicarboxylic acid metabolic process
cerebellum development
nucleoside metabolic process
metencephalon development
cerebral cortex development
glycosyl compound metabolic process
coenzyme biosynthetic process
purine ribonucleotide biosynthetic process
hindbrain development
purine nucleotide biosynthetic process
regeneration
ribonucleotide biosynthetic process
ribose phosphate biosynthetic process
purine-containing compound biosynthetic process
pallium development