ATOH1
Gene Information
- Official Symbol: ATOH1
- Official Name: atonal bHLH transcription factor 1
- Aliases and Previous Symbols: N/A
- Entrez ID: 474
- UniProt: Q92858
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Transcriptional regulator. Activates E box-dependent transcription in collaboration with TCF3/E47, but the activity is completely antagonized by the negative regulator of neurogenesis HES1. Plays a role in the differentiation of subsets of neural cells by activating E box-dependent transcription (By similarity). {ECO:0000250}.
Pfam Domains GO Terms
Pfam Domains
| HLH |
GO Terms
| auditory receptor cell fate determination |
| auditory receptor cell fate specification |
| positive regulation of inner ear receptor cell differentiation |
| positive regulation of inner ear auditory receptor cell differentiation |
| positive regulation of mechanoreceptor differentiation |
| positive regulation of neuroepithelial cell differentiation |
| auditory receptor cell fate commitment |
| inner ear receptor cell fate commitment |
| neuron fate determination |
| regulation of inner ear auditory receptor cell differentiation |
| regulation of inner ear receptor cell differentiation |
| regulation of mechanoreceptor differentiation |
| epithelial cell fate commitment |
| positive regulation of epidermal cell differentiation |
| inner ear auditory receptor cell differentiation |
| neuron fate specification |
| hair cell differentiation |
| cell fate determination |
| positive regulation of epidermis development |
| neuroepithelial cell differentiation |
| inner ear receptor cell differentiation |
| mechanoreceptor differentiation |
| positive regulation of epithelial cell differentiation |
| regulation of epidermal cell differentiation |
| neuron fate commitment |
| chromatin DNA binding |
| regulation of epidermis development |
| cell fate specification |
| columnar/cuboidal epithelial cell differentiation |
| inner ear morphogenesis |
| cerebral cortex development |
| ear morphogenesis |
| neuron migration |
| Notch signaling pathway |
| regulation of epithelial cell differentiation |
| protein dimerization activity |
| pallium development |
| inner ear development |
| ear development |
| cell fate commitment |
| sensory organ morphogenesis |
| telencephalon development |
| axon guidance |
| neuron projection guidance |
| embryonic organ morphogenesis |
| epidermal cell differentiation |
| positive regulation of neuron differentiation |
| axonogenesis |
| forebrain development |
| axon development |
| epidermis development |
| cell morphogenesis involved in neuron differentiation |
| embryonic organ development |
| DNA-binding transcription activator activity, RNA polymerase II-specific |
| positive regulation of neurogenesis |
| neuron projection morphogenesis |
| transcription by RNA polymerase II |
| plasma membrane bounded cell projection morphogenesis |
| cell projection morphogenesis |
| RNA polymerase II proximal promoter sequence-specific DNA binding |
| cell part morphogenesis |
| positive regulation of nervous system development |
| positive regulation of cell development |
| sensory organ development |
| chemotaxis |
| taxis |
| cell morphogenesis involved in differentiation |
| embryonic morphogenesis |
| transcription, DNA-templated |
| nucleic acid-templated transcription |
| RNA biosynthetic process |
| regulation of neuron differentiation |
| neuron projection development |
| DNA-binding transcription factor activity |
| epithelial cell differentiation |
| cell morphogenesis |
| brain development |
| head development |
| neuron development |
| regulation of neurogenesis |
| cellular component morphogenesis |
| negative regulation of apoptotic process |
| negative regulation of programmed cell death |
| regulation of nervous system development |
| regulation of cell development |
| animal organ morphogenesis |
| cell migration |
| positive regulation of cell differentiation |
| embryo development |
| central nervous system development |
| negative regulation of cell death |
| neuron differentiation |
| cell motility |
| localization of cell |
| nucleobase-containing compound biosynthetic process |
| epithelium development |
| plasma membrane bounded cell projection organization |
| cell projection organization |
| heterocycle biosynthetic process |
| aromatic compound biosynthetic process |
| positive regulation of transcription by RNA polymerase II |
| organic cyclic compound biosynthetic process |
| locomotion |
| positive regulation of developmental process |
| generation of neurons |
| positive regulation of transcription, DNA-templated |
| regulation of apoptotic process |
| movement of cell or subcellular component |
| DNA-binding transcription factor activity, RNA polymerase II-specific |
| regulation of programmed cell death |
| neurogenesis |
| cellular nitrogen compound biosynthetic process |
| positive regulation of nucleic acid-templated transcription |
| positive regulation of RNA biosynthetic process |
| cell development |
| RNA metabolic process |
| regulation of cell death |
| cellular macromolecule biosynthetic process |
| positive regulation of RNA metabolic process |
| positive regulation of multicellular organismal process |
| tissue development |
| macromolecule biosynthetic process |
| regulation of cell differentiation |
| positive regulation of nucleobase-containing compound metabolic process |
| positive regulation of macromolecule biosynthetic process |
| positive regulation of cellular biosynthetic process |
| positive regulation of gene expression |
| gene expression |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| CyclicAMP 200μM R08 exp475 | 1.8 |
| Cyclosporin-A 0.8μM R07 exp347 | 1.91 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 1/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 1/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 11980
- Expression level (log2 read counts): -6.6
Expression Distribution
ATOH1 Expression in NALM6 Cells: -6.6
