ATP13A2

Entrez Summary: This gene encodes a member of the P5 subfamily of ATPases which transports inorganic cations as well as other substrates. Mutations in this gene are associated with Kufor-Rakeb syndrome (KRS), also referred to as Parkinson disease 9. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Nov 2008].
UniProt Summary: ATPase that plays a role in intracellular cation homeostasis and the maintenance of neuronal integrity (PubMed:22186024). Required for a proper lysosomal and mitochondrial maintenance (PubMed:22296644, PubMed:28137957). {ECO:0000269|PubMed:22186024, ECO:0000269|PubMed:22296644, ECO:0000269|PubMed:28137957}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

peptidyl-aspartic acid phosphorylation
peptidyl-aspartic acid autophosphorylation
polyamine transmembrane transport
regulation of autophagosome size
regulation of glucosylceramidase activity
ATPase-coupled cation transmembrane transporter activity
peptidyl-aspartic acid modification
integral component of lysosomal membrane
cupric ion binding
polyamine transport
negative regulation of lysosomal protein catabolic process
negative regulation of protein catabolic process in the vacuole
extracellular exosome biogenesis
extracellular vesicle biogenesis
regulation of chaperone-mediated autophagy
regulation of lysosomal protein catabolic process
regulation of protein catabolic process in the vacuole
cellular response to manganese ion
multivesicular body membrane
positive regulation of exosomal secretion
regulation of exosomal secretion
response to manganese ion
phosphatidic acid binding
cellular response to zinc ion
phosphatidylinositol-3,5-bisphosphate binding
vesicle membrane
multivesicular body
cellular zinc ion homeostasis
zinc ion homeostasis
regulation of autophagy of mitochondrion
response to zinc ion
cellular iron ion homeostasis
manganese ion binding
autophagosome organization
autophagosome
iron ion homeostasis
negative regulation of cellular protein catabolic process
positive regulation of exocytosis
transport vesicle
lysosomal lumen