ATP1A4

Entrez Summary: N/A
UniProt Summary: This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients. Plays a role in sperm motility.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

sodium:potassium-exchanging ATPase activity
sodium:potassium-exchanging ATPase complex
cellular potassium ion homeostasis
sodium ion export across plasma membrane
establishment or maintenance of transmembrane electrochemical gradient
cellular sodium ion homeostasis
potassium ion homeostasis
sodium ion homeostasis
export across plasma membrane
potassium ion import across plasma membrane
regulation of cardiac conduction
flagellated sperm motility
sperm motility
inorganic ion import across plasma membrane
inorganic cation import across plasma membrane
sodium ion transmembrane transport
regulation of cellular pH
cilium-dependent cell motility
cilium or flagellum-dependent cell motility
import across plasma membrane
regulation of pH
cellular monovalent inorganic cation homeostasis
monovalent inorganic cation homeostasis
proton transmembrane transport
sodium ion transport
potassium ion transmembrane transport
potassium ion transport
fertilization
regulation of heart contraction
regulation of blood circulation
monovalent inorganic cation transport
regulation of membrane potential
spermatogenesis
cellular metal ion homeostasis
inorganic cation transmembrane transport
male gamete generation
regulation of system process
cation transmembrane transport
metal ion homeostasis
cellular cation homeostasis