ATP1B3 [The Human Chemical-Genetic Interaction Map Project]

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======= ATP1B3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ATP1B3
  * **<color #00a2e8>Official Name</color>**: ATPase Na+/K+ transporting subunit beta 3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=483|483]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P54709|P54709]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ATP1B3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ATP1B3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/601867|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The exact function of the beta-3 subunit is not known.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Na K-ATPase|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of sodium ion export across plasma membrane|
|regulation of sodium ion export across plasma membrane|
|positive regulation of potassium ion import across plasma membrane|
|regulation of potassium ion import|
|sodium:potassium-exchanging ATPase activity|
|sodium:potassium-exchanging ATPase complex|
|sodium ion export across plasma membrane|
|cellular potassium ion homeostasis|
|establishment or maintenance of transmembrane electrochemical gradient|
|cellular sodium ion homeostasis|
|positive regulation of sodium ion transmembrane transport|
|membrane repolarization|
|ATPase activator activity|
|positive regulation of potassium ion transmembrane transporter activity|
|potassium ion homeostasis|
|sodium ion homeostasis|
|positive regulation of sodium ion transport|
|positive regulation of potassium ion transmembrane transport|
|export across plasma membrane|
|potassium ion import across plasma membrane|
|positive regulation of potassium ion transport|
|positive regulation of ATPase activity|
|regulation of potassium ion transmembrane transporter activity|
|regulation of sodium ion transmembrane transport|
|regulation of cardiac conduction|
|caveola|
|inorganic cation import across plasma membrane|
|inorganic ion import across plasma membrane|
|regulation of potassium ion transmembrane transport|
|ATPase binding|
|regulation of ATPase activity|
|regulation of sodium ion transport|
|sodium ion transmembrane transport|
|regulation of potassium ion transport|
|import across plasma membrane|
|melanosome|
|positive regulation of ion transmembrane transporter activity|
|cellular monovalent inorganic cation homeostasis|
|positive regulation of transporter activity|
|monovalent inorganic cation homeostasis|
|positive regulation of cation transmembrane transport|
|sodium ion transport|
|positive regulation of ion transmembrane transport|
|potassium ion transmembrane transport|
|potassium ion transport|
|protein stabilization|
|protein localization to plasma membrane|
|positive regulation of transmembrane transport|
|protein localization to cell periphery|
|regulation of heart contraction|
|regulation of ion transmembrane transporter activity|
|regulation of transmembrane transporter activity|
|positive regulation of ion transport|
|regulation of transporter activity|
|regulation of protein stability|
|regulation of blood circulation|
|regulation of cation transmembrane transport|
|leukocyte migration|
|regulation of metal ion transport|
|monovalent inorganic cation transport|
|regulation of membrane potential|
|regulation of ion transmembrane transport|
|protein localization to membrane|
|cellular metal ion homeostasis|
|inorganic cation transmembrane transport|
|regulation of transmembrane transport|
|regulation of system process|
|cation transmembrane transport|
|metal ion homeostasis|
|cellular cation homeostasis|
|metal ion transport|
|cellular ion homeostasis|
|inorganic ion transmembrane transport|
|import into cell|
|regulation of ion transport|
|cation homeostasis|
|inorganic ion homeostasis|
|cellular chemical homeostasis|
|positive regulation of hydrolase activity|
|ion homeostasis|
|cation transport|
|cellular homeostasis|
|ion transmembrane transport|
|cell migration|
|positive regulation of transport|
|export from cell|
|cell motility|
|localization of cell|
|chemical homeostasis|
|regulation of hydrolase activity|
|transmembrane transport|
|locomotion|
|ion transport|
|positive regulation of catalytic activity|
|movement of cell or subcellular component|
|cellular protein localization|
|cellular macromolecule localization|
|homeostatic process|
|positive regulation of molecular function|
|regulation of transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp380|NMS-873 0.07μM R07 exp380]]|-1.84|
|[[:results:exp179|Combretastatin A4 0.002 to 0.003μM day4 R04 exp179]]|2.79|
|[[:results:exp106|UM131593 0.2μM R03 exp106]]|2.86|
|[[:results:exp215|Colchicine 0.009μM R05 exp215]]|3.12|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:a:atp1a1|ATP1A1]]|0.613|
|[[:human genes:t:tmem161b|TMEM161B]]|0.518|
|[[:human genes:t:tmx2|TMX2]]|0.414|
|[[:human genes:n:ndrg3|NDRG3]]|0.41|
|[[:human genes:p:pigo|PIGO]]|0.41|
|[[:human genes:n:numa1|NUMA1]]|0.401|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 49/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|9/28|
|bone|2/26|
|breast|4/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|1/21|
|liver|0/20|
|lung|2/75|
|lymphocyte|8/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|6/15|
|prostate|0/1|
|skin|2/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1642
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 8.23 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ATP1B3 Expression in NALM6 Cells: 8.23'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>