ATP1B3
Gene Information
- Official Symbol: ATP1B3
- Official Name: ATPase Na+/K+ transporting subunit beta 3
- Aliases and Previous Symbols: N/A
- Entrez ID: 483
- UniProt: P54709
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The exact function of the beta-3 subunit is not known.
Pfam Domains GO Terms
Pfam Domains
| Na K-ATPase |
GO Terms
| positive regulation of sodium ion export across plasma membrane |
| regulation of sodium ion export across plasma membrane |
| positive regulation of potassium ion import across plasma membrane |
| regulation of potassium ion import |
| sodium:potassium-exchanging ATPase activity |
| sodium:potassium-exchanging ATPase complex |
| sodium ion export across plasma membrane |
| cellular potassium ion homeostasis |
| establishment or maintenance of transmembrane electrochemical gradient |
| cellular sodium ion homeostasis |
| positive regulation of sodium ion transmembrane transport |
| membrane repolarization |
| ATPase activator activity |
| positive regulation of potassium ion transmembrane transporter activity |
| potassium ion homeostasis |
| sodium ion homeostasis |
| positive regulation of sodium ion transport |
| positive regulation of potassium ion transmembrane transport |
| export across plasma membrane |
| potassium ion import across plasma membrane |
| positive regulation of potassium ion transport |
| positive regulation of ATPase activity |
| regulation of potassium ion transmembrane transporter activity |
| regulation of sodium ion transmembrane transport |
| regulation of cardiac conduction |
| caveola |
| inorganic cation import across plasma membrane |
| inorganic ion import across plasma membrane |
| regulation of potassium ion transmembrane transport |
| ATPase binding |
| regulation of ATPase activity |
| regulation of sodium ion transport |
| sodium ion transmembrane transport |
| regulation of potassium ion transport |
| import across plasma membrane |
| melanosome |
| positive regulation of ion transmembrane transporter activity |
| cellular monovalent inorganic cation homeostasis |
| positive regulation of transporter activity |
| monovalent inorganic cation homeostasis |
| positive regulation of cation transmembrane transport |
| sodium ion transport |
| positive regulation of ion transmembrane transport |
| potassium ion transmembrane transport |
| potassium ion transport |
| protein stabilization |
| protein localization to plasma membrane |
| positive regulation of transmembrane transport |
| protein localization to cell periphery |
| regulation of heart contraction |
| regulation of ion transmembrane transporter activity |
| regulation of transmembrane transporter activity |
| positive regulation of ion transport |
| regulation of transporter activity |
| regulation of protein stability |
| regulation of blood circulation |
| regulation of cation transmembrane transport |
| leukocyte migration |
| regulation of metal ion transport |
| monovalent inorganic cation transport |
| regulation of membrane potential |
| regulation of ion transmembrane transport |
| protein localization to membrane |
| cellular metal ion homeostasis |
| inorganic cation transmembrane transport |
| regulation of transmembrane transport |
| regulation of system process |
| cation transmembrane transport |
| metal ion homeostasis |
| cellular cation homeostasis |
| metal ion transport |
| cellular ion homeostasis |
| inorganic ion transmembrane transport |
| import into cell |
| regulation of ion transport |
| cation homeostasis |
| inorganic ion homeostasis |
| cellular chemical homeostasis |
| positive regulation of hydrolase activity |
| ion homeostasis |
| cation transport |
| cellular homeostasis |
| ion transmembrane transport |
| cell migration |
| positive regulation of transport |
| export from cell |
| cell motility |
| localization of cell |
| chemical homeostasis |
| regulation of hydrolase activity |
| transmembrane transport |
| locomotion |
| ion transport |
| positive regulation of catalytic activity |
| movement of cell or subcellular component |
| cellular protein localization |
| cellular macromolecule localization |
| homeostatic process |
| positive regulation of molecular function |
| regulation of transport |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 49/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 9/28 |
| bone | 2/26 |
| breast | 4/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 1/21 |
| liver | 0/20 |
| lung | 2/75 |
| lymphocyte | 8/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 6/15 |
| prostate | 0/1 |
| skin | 2/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 1642
- Expression level (log2 read counts): 8.23
Expression Distribution
ATP1B3 Expression in NALM6 Cells: 8.23
