ATP6V1G2

Entrez Summary: N/A
UniProt Summary: Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

vacuolar proton-transporting V-type ATPase complex
proton-exporting ATPase activity, phosphorylative mechanism
phagosome acidification
transferrin transport
phagosome maturation
intracellular pH reduction
pH reduction
ATPase-coupled transmembrane transporter activity
iron ion transport
regulation of intracellular pH
insulin receptor signaling pathway
regulation of cellular pH
regulation of pH
melanosome
cellular monovalent inorganic cation homeostasis
transition metal ion transport
monovalent inorganic cation homeostasis
proton transmembrane transport
cellular response to insulin stimulus
regulation of macroautophagy
response to insulin
cellular response to peptide hormone stimulus
cellular response to peptide
regulation of autophagy
response to peptide hormone
monovalent inorganic cation transport
response to peptide
transmembrane receptor protein tyrosine kinase signaling pathway
inorganic cation transmembrane transport
cellular response to organonitrogen compound
cellular response to hormone stimulus
cation transmembrane transport
cellular cation homeostasis
metal ion transport
cellular ion homeostasis
inorganic ion transmembrane transport
cellular response to nitrogen compound
cation homeostasis
enzyme linked receptor protein signaling pathway
inorganic ion homeostasis