AVPR1A
Gene Information
- Official Symbol: AVPR1A
- Official Name: arginine vasopressin receptor 1A
- Aliases and Previous Symbols: N/A
- Entrez ID: 552
- UniProt: P37288
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl- inositol-calcium second messenger system. Has been involved in social behaviors, including affiliation and attachment. {ECO:0000269|PubMed:12082568}.
Pfam Domains GO Terms
Pfam Domains
| 7TM GPCR Srsx |
| 7tm 1 |
| DUF1856 |
| 7TM GPCR Srv |
GO Terms
| V1A vasopressin receptor binding |
| penile erection |
| cellular response to water deprivation |
| maternal aggressive behavior |
| negative regulation of female receptivity |
| positive regulation of cellular pH reduction |
| cellular response to water stimulus |
| regulation of systemic arterial blood pressure by vasopressin |
| regulation of cellular pH reduction |
| sperm ejaculation |
| positive regulation of prostaglandin biosynthetic process |
| negative regulation of transmission of nerve impulse |
| vasopressin receptor activity |
| regulation of female receptivity |
| positive regulation of unsaturated fatty acid biosynthetic process |
| aggressive behavior |
| female mating behavior |
| response to water deprivation |
| regulation of prostaglandin biosynthetic process |
| positive regulation of glutamate secretion |
| regulation of unsaturated fatty acid biosynthetic process |
| insemination |
| parental behavior |
| maternal behavior |
| positive regulation of systemic arterial blood pressure |
| grooming behavior |
| positive regulation of renal sodium excretion |
| response to water |
| copulation |
| regulation of glutamate secretion |
| regulation of transmission of nerve impulse |
| positive regulation of amino acid transport |
| positive regulation of fatty acid biosynthetic process |
| mating behavior |
| response to corticosterone |
| regulation of renal sodium excretion |
| positive regulation of heart rate |
| regulation of excretion |
| negative regulation of nervous system process |
| reproductive behavior |
| positive regulation of vasoconstriction |
| regulation of amino acid transport |
| activation of phospholipase C activity |
| response to mineralocorticoid |
| mating |
| positive regulation of organic acid transport |
| positive regulation of fatty acid metabolic process |
| positive regulation of amine transport |
| regulation of renal system process |
| positive regulation of blood pressure |
| regulation of systemic arterial blood pressure by hormone |
| positive regulation of heart contraction |
| peptide hormone binding |
| positive regulation of phospholipase C activity |
| regulation of fatty acid biosynthetic process |
| regulation of systemic arterial blood pressure mediated by a chemical signal |
| regulation of phospholipase C activity |
| endocrine process |
| positive regulation of anion transport |
| social behavior |
| intraspecies interaction between organisms |
| protein kinase C binding |
| regulation of vasoconstriction |
| myotube differentiation |
| regulation of organic acid transport |
| positive regulation of phospholipase activity |
| multi-organism behavior |
| positive regulation of blood circulation |
| regulation of phospholipase activity |
| positive regulation of lipase activity |
| positive regulation of lipid biosynthetic process |
| regulation of intracellular pH |
| regulation of fatty acid metabolic process |
| regulation of cellular pH |
| regulation of systemic arterial blood pressure |
| regulation of amine transport |
| regulation of anion transport |
| regulation of heart rate |
| regulation of lipase activity |
| regulation of pH |
| cellular monovalent inorganic cation homeostasis |
| regulation of nervous system process |
| positive regulation of small molecule metabolic process |
| regulation of blood vessel diameter |
| regulation of tube diameter |
| monovalent inorganic cation homeostasis |
| regulation of tube size |
| positive regulation of lipid metabolic process |
| response to glucocorticoid |
| calcium-mediated signaling |
| response to corticosteroid |
| positive regulation of cell growth |
| vascular process in circulatory system |
| regulation of cellular ketone metabolic process |
| regulation of blood pressure |
| regulation of lipid biosynthetic process |
| response to ketone |
| striated muscle cell differentiation |
| cellular response to acid chemical |
| multi-multicellular organism process |
| response to alcohol |
| regulation of heart contraction |
| muscle cell differentiation |
| telencephalon development |
| positive regulation of growth |
| cellular response to extracellular stimulus |
| endosome |
| positive regulation of ion transport |
| positive regulation of cytosolic calcium ion concentration |
| regulation of blood circulation |
| cellular response to abiotic stimulus |
| cellular response to environmental stimulus |
| response to steroid hormone |
| regulation of cytosolic calcium ion concentration |
| cellular response to external stimulus |
| second-messenger-mediated signaling |
| response to acid chemical |
| forebrain development |
| blood circulation |
| circulatory system process |
| regulation of lipid metabolic process |
| positive regulation of secretion by cell |
| regulation of cell growth |
| generation of precursor metabolites and energy |
| regulation of small molecule metabolic process |
| positive regulation of secretion |
| cellular calcium ion homeostasis |
| calcium ion homeostasis |
| cellular divalent inorganic cation homeostasis |
| muscle structure development |
| divalent inorganic cation homeostasis |
| regulation of anatomical structure size |
| response to extracellular stimulus |
| response to inorganic substance |
| cellular metal ion homeostasis |
| behavior |
| regulation of system process |
| cellular response to hormone stimulus |
| metal ion homeostasis |
| cellular cation homeostasis |
| cellular ion homeostasis |
| regulation of growth |
| regulation of ion transport |
| cation homeostasis |
| inorganic ion homeostasis |
| brain development |
| cellular chemical homeostasis |
| regulation of secretion by cell |
| positive regulation of hydrolase activity |
| head development |
| ion homeostasis |
| regulation of secretion |
| multicellular organismal reproductive process |
| sexual reproduction |
| multicellular organism reproduction |
| response to lipid |
| cellular homeostasis |
| response to hormone |
| positive regulation of cell population proliferation |
| response to organic cyclic compound |
| central nervous system development |
| positive regulation of transport |
| multi-organism reproductive process |
| cellular response to oxygen-containing compound |
| chemical homeostasis |
| response to abiotic stimulus |
| negative regulation of multicellular organismal process |
| cellular response to endogenous stimulus |
| regulation of hydrolase activity |
| G protein-coupled receptor signaling pathway |
| negative regulation of cell communication |
| negative regulation of signaling |
| integral component of plasma membrane |
| reproductive process |
| reproduction |
| positive regulation of catalytic activity |
| response to endogenous stimulus |
| response to oxygen-containing compound |
| regulation of cell population proliferation |
| homeostatic process |
| intracellular signal transduction |
| cellular response to stress |
| positive regulation of multicellular organismal process |
| positive regulation of molecular function |
| regulation of transport |
| system process |
| positive regulation of cellular biosynthetic process |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
No hits were found.
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 1/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 1/5 |
Essentiality in NALM6
- Essentiality Rank: 13465
- Expression level (log2 read counts): 0.53
Expression Distribution
AVPR1A Expression in NALM6 Cells: 0.53
