AZI2

Entrez Summary: N/A
UniProt Summary: Adapter protein which binds TBK1 and IKBKE playing a role in antiviral innate immunity. Activates serine/threonine- protein kinase TBK1 and facilitates its oligomerization. Enhances the phosphorylation of NF-kappa-B p65 subunit RELA by TBK1. Promotes TBK1-induced as well as TNF-alpha or PMA-induced activation of NF-kappa-B. Participates in IFNB promoter activation via TICAM1. {ECO:0000269|PubMed:14560022, ECO:0000269|PubMed:15611223, ECO:0000269|PubMed:21931631}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
RO-3307 4.7μM R02 exp80	-1.99
Rotenone 20μM R00 exp34	-1.95
2-Methoxyestradiol 0.55 to 1μM on day4 R07 exp312	-1.78

dendritic cell proliferation
interferon-alpha production
tumor necrosis factor production
type I interferon production
tumor necrosis factor superfamily cytokine production
interleukin-6 production
interferon-gamma production
dendritic cell differentiation
I-kappaB kinase/NF-kappaB signaling
lymphocyte proliferation
mononuclear cell proliferation
leukocyte proliferation
cytokine production
T cell activation
leukocyte differentiation
lymphocyte activation
cell population proliferation
hemopoiesis
hematopoietic or lymphoid organ development
immune system development
mitotic cell cycle
viral process
symbiotic process
interspecies interaction between organisms
leukocyte activation
cell activation
cell cycle
intracellular signal transduction