B3GNT5

Official Symbol: B3GNT5
Official Name: UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5
Aliases and Previous Symbols: N/A
Entrez ID: 84002
UniProt: Q9BYG0
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Entrez Summary: N/A
UniProt Summary: Beta-1,3-N-acetylglucosaminyltransferase that plays a key role in the synthesis of lacto- or neolacto-series carbohydrate chains on glycolipids, notably by participating in biosynthesis of HNK-1 and Lewis X carbohydrate structures. Has strong activity toward lactosylceramide (LacCer) and neolactotetraosylceramide (nLc(4)Cer; paragloboside), resulting in the synthesis of Lc(3)Cer and neolactopentaosylceramide (nLc(5)Cer), respectively. Probably plays a central role in regulating neolacto-series glycolipid synthesis during embryonic development.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

beta-galactosyl-N-acetylglucosaminylgalactosylglucosyl-ceramide beta-1,3-acetylglucosaminyltransferase activity
lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase activity
N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity
poly-N-acetyllactosamine biosynthetic process
poly-N-acetyllactosamine metabolic process
galactosyltransferase activity
acetylgalactosaminyltransferase activity
cellular polysaccharide biosynthetic process
polysaccharide biosynthetic process
cellular carbohydrate biosynthetic process
O-glycan processing
glycolipid biosynthetic process
cellular polysaccharide metabolic process
polysaccharide metabolic process
aminoglycan biosynthetic process
glycolipid metabolic process
liposaccharide metabolic process
protein O-linked glycosylation
carbohydrate biosynthetic process
membrane lipid biosynthetic process
aminoglycan metabolic process
cellular carbohydrate metabolic process
membrane lipid metabolic process
macromolecule glycosylation
protein glycosylation
glycosylation
glycoprotein biosynthetic process
glycoprotein metabolic process
carbohydrate metabolic process
lipid biosynthetic process
Golgi membrane
carbohydrate derivative biosynthetic process
brain development
head development
cellular lipid metabolic process
central nervous system development
Golgi apparatus
endoplasmic reticulum
carbohydrate derivative metabolic process
lipid metabolic process