B4GALNT1

Entrez Summary: GM2 and GD2 gangliosides are sialic acid-containing glycosphingolipids. GalNAc-T is the enzyme involved in the biosynthesis of G(M2) and G(D2) glycosphingolipids. GalNAc-T catalyzes the transfer of GalNAc into G(M3) and G(D3) by a beta-1,4 linkage, resulting in the synthesis of G(M2) and G(D2), respectively. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2013].
UniProt Summary: Involved in the biosynthesis of gangliosides GM2, GD2 and GA2. {ECO:0000269|PubMed:1601877}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

(N-acetylneuraminyl)-galactosylglucosylceramide N-acetylgalactosaminyltransferase activity
ganglioside biosynthetic process
lipid glycosylation
ganglioside metabolic process
glycosphingolipid biosynthetic process
lipid storage
ceramide biosynthetic process
integral component of Golgi membrane
glycosphingolipid metabolic process
glycolipid biosynthetic process
ceramide metabolic process
sphingolipid biosynthetic process
glycolipid metabolic process
liposaccharide metabolic process
membrane lipid biosynthetic process
sphingolipid metabolic process
maintenance of location
lipid modification
membrane lipid metabolic process
glycosylation
lipid localization
carbohydrate metabolic process
amide biosynthetic process
spermatogenesis
male gamete generation
lipid biosynthetic process
Golgi membrane
carbohydrate derivative biosynthetic process
gamete generation
cellular amide metabolic process
multicellular organismal reproductive process
sexual reproduction
multicellular organism reproduction
cellular lipid metabolic process
multi-organism reproductive process
carbohydrate derivative metabolic process
lipid metabolic process
organonitrogen compound biosynthetic process
reproductive process
reproduction