BACE1

Entrez Summary: This gene encodes a member of the peptidase A1 family of aspartic proteases. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature protease. This transmembrane protease catalyzes the first step in the formation of amyloid beta peptide from amyloid precursor protein. Amyloid beta peptides are the main constituent of amyloid beta plaques, which accumulate in the brains of human Alzheimer's disease patients. [provided by RefSeq, Nov 2015].
UniProt Summary: N/A

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Golgi-associated vesicle lumen
beta-aspartyl-peptidase activity
cellular response to manganese ion
detection of mechanical stimulus involved in sensory perception of pain
prepulse inhibition
response to manganese ion
amyloid-beta metabolic process
aspartic-type endopeptidase activity
membrane protein ectodomain proteolysis
response to lead ion
startle response
detection of mechanical stimulus involved in sensory perception
cellular response to copper ion
multivesicular body
hippocampal mossy fiber to CA3 synapse
membrane protein proteolysis
cellular response to amyloid-beta
detection of mechanical stimulus
response to copper ion
response to amyloid-beta
positive regulation of neuron apoptotic process
sensory perception of pain
endopeptidase activity
regulation of synaptic vesicle exocytosis
peptidase activity
amyloid-beta binding
positive regulation of neuron death
regulation of neurotransmitter secretion
neuromuscular process
regulation of synaptic vesicle cycle
recycling endosome
synaptic vesicle
detection of external stimulus
detection of abiotic stimulus
late endosome
cytoplasmic vesicle membrane
regulation of neurotransmitter transport
regulation of regulated secretory pathway
sensory perception of mechanical stimulus
trans-Golgi network