BACE2

Entrez Summary: N/A
UniProt Summary: Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves APP, between residues 690 and 691, leading to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C- terminal fragment which is later released by gamma-secretase. It has also been shown that it can cleave APP between residues 671 and 672. {ECO:0000269|PubMed:10591213, ECO:0000269|PubMed:11083922, ECO:0000269|PubMed:11423558, ECO:0000269|PubMed:15857888, ECO:0000269|PubMed:16816112}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

negative regulation of amyloid precursor protein biosynthetic process
regulation of amyloid precursor protein biosynthetic process
negative regulation of glycoprotein biosynthetic process
dense core granule
negative regulation of glycoprotein metabolic process
astrocyte activation
amyloid-beta metabolic process
aspartic-type endopeptidase activity
membrane protein ectodomain proteolysis
peptide hormone processing
astrocyte development
membrane protein proteolysis
glial cell activation
regulation of glycoprotein biosynthetic process
neuroinflammatory response
regulation of glycoprotein metabolic process
astrocyte differentiation
amyloid-beta binding
glial cell development
protein processing
trans-Golgi network
glial cell differentiation
glucose homeostasis
carbohydrate homeostasis
hormone metabolic process
gliogenesis
protein maturation
endosome
inflammatory response
peptide metabolic process
regulation of hormone levels
protein catabolic process
cellular amide metabolic process
central nervous system development
Golgi apparatus
endoplasmic reticulum
macromolecule catabolic process
organonitrogen compound catabolic process
cell activation
negative regulation of protein metabolic process