BACH1 [The Human Chemical-Genetic Interaction Map Project]

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======= BACH1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: BACH1
  * **<color #00a2e8>Official Name</color>**: BTB domain and CNC homolog 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=571|571]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O14867|O14867]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=BACH1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20BACH1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602751|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a transcription factor that belongs to the cap'n'collar type of basic region leucine zipper factor family (CNC-bZip). The encoded protein contains broad complex, tramtrack, bric-a-brac/poxvirus and zinc finger (BTB/POZ) domains, which is atypical of CNC-bZip family members. These BTB/POZ domains facilitate protein-protein interactions and formation of homo- and/or hetero-oligomers. When this encoded protein forms a heterodimer with MafK, it functions as a repressor of Maf recognition element (MARE) and transcription is repressed. Multiple alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq, May 2009]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Transcriptional regulator that acts as repressor or activator. Binds, in vitro, to NF-E2 binding sites. Play important roles in coordinating transcription activation and repression by MAFK.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|bZIP 1|
|BTB|
|bZIP 2|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|regulation of transcription involved in G2/M transition of mitotic cell cycle|
|regulation of transcription involved in G1/S transition of mitotic cell cycle|
|regulation of transcription from RNA polymerase II promoter in response to hypoxia|
|RNA polymerase II distal enhancer sequence-specific DNA binding|
|regulation of transcription from RNA polymerase II promoter in response to stress|
|G1/S transition of mitotic cell cycle|
|cell cycle G1/S phase transition|
|regulation of DNA-templated transcription in response to stress|
|G2/M transition of mitotic cell cycle|
|cell cycle G2/M phase transition|
|heme binding|
|cellular response to hypoxia|
|cellular response to decreased oxygen levels|
|cellular response to oxygen levels|
|DNA-binding transcription repressor activity, RNA polymerase II-specific|
|mitotic cell cycle phase transition|
|cell cycle phase transition|
|response to hypoxia|
|response to decreased oxygen levels|
|response to oxygen levels|
|DNA-binding transcription activator activity, RNA polymerase II-specific|
|DNA repair|
|mitotic cell cycle process|
|DNA-binding transcription factor activity|
|mitotic cell cycle|
|DNA metabolic process|
|cellular response to DNA damage stimulus|
|negative regulation of transcription by RNA polymerase II|
|cell cycle process|
|response to abiotic stimulus|
|negative regulation of transcription, DNA-templated|
|positive regulation of transcription by RNA polymerase II|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|negative regulation of RNA metabolic process|
|cell cycle|
|negative regulation of cellular macromolecule biosynthetic process|
|negative regulation of nucleobase-containing compound metabolic process|
|negative regulation of macromolecule biosynthetic process|
|negative regulation of cellular biosynthetic process|
|positive regulation of transcription, DNA-templated|
|negative regulation of biosynthetic process|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|cellular response to stress|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp42|BI-6727 0.001μM R01 exp42]]|-1.85|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 18533
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.86 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='BACH1 Expression in NALM6 Cells: 4.86'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>