BACH1

Gene Information

Official Symbol: BACH1
Official Name: BTB domain and CNC homolog 1
Aliases and Previous Symbols: N/A
Entrez ID: 571
UniProt: O14867
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene encodes a transcription factor that belongs to the cap'n'collar type of basic region leucine zipper factor family (CNC-bZip). The encoded protein contains broad complex, tramtrack, bric-a-brac/poxvirus and zinc finger (BTB/POZ) domains, which is atypical of CNC-bZip family members. These BTB/POZ domains facilitate protein-protein interactions and formation of homo- and/or hetero-oligomers. When this encoded protein forms a heterodimer with MafK, it functions as a repressor of Maf recognition element (MARE) and transcription is repressed. Multiple alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq, May 2009].
UniProt Summary: Transcriptional regulator that acts as repressor or activator. Binds, in vitro, to NF-E2 binding sites. Play important roles in coordinating transcription activation and repression by MAFK.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 18533
Expression level (log2 read counts): 4.86

Expression Distribution

bZIP 1
BTB
bZIP 2

regulation of transcription involved in G2/M transition of mitotic cell cycle
regulation of transcription involved in G1/S transition of mitotic cell cycle
regulation of transcription from RNA polymerase II promoter in response to hypoxia
RNA polymerase II distal enhancer sequence-specific DNA binding
regulation of transcription from RNA polymerase II promoter in response to stress
G1/S transition of mitotic cell cycle
cell cycle G1/S phase transition
regulation of DNA-templated transcription in response to stress
G2/M transition of mitotic cell cycle
cell cycle G2/M phase transition
heme binding
cellular response to hypoxia
cellular response to decreased oxygen levels
cellular response to oxygen levels
DNA-binding transcription repressor activity, RNA polymerase II-specific
mitotic cell cycle phase transition
cell cycle phase transition
response to hypoxia
response to decreased oxygen levels
response to oxygen levels
DNA-binding transcription activator activity, RNA polymerase II-specific
DNA repair
mitotic cell cycle process
DNA-binding transcription factor activity
mitotic cell cycle
DNA metabolic process
cellular response to DNA damage stimulus
negative regulation of transcription by RNA polymerase II
cell cycle process
response to abiotic stimulus
negative regulation of transcription, DNA-templated
positive regulation of transcription by RNA polymerase II
negative regulation of nucleic acid-templated transcription
negative regulation of RNA biosynthetic process
negative regulation of RNA metabolic process
cell cycle
negative regulation of cellular macromolecule biosynthetic process
negative regulation of nucleobase-containing compound metabolic process
negative regulation of macromolecule biosynthetic process
negative regulation of cellular biosynthetic process