BAD [The Human Chemical-Genetic Interaction Map Project]

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======= BAD =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: BAD
  * **<color #00a2e8>Official Name</color>**: BCL2 associated agonist of cell death
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=572|572]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q92934|Q92934]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=BAD&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20BAD|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603167|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Promotes cell death. Successfully competes for the binding to Bcl-X(L), Bcl-2 and Bcl-W, thereby affecting the level of heterodimerization of these proteins with BAX. Can reverse the death repressor activity of Bcl-X(L), but not that of Bcl-2 (By similarity). Appears to act as a link between growth factor receptor signaling and the apoptotic pathways. {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Bcl-2 BAD|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|response to chromate|
|positive regulation of granulosa cell apoptotic process|
|positive regulation of intrinsic apoptotic signaling pathway in response to osmotic stress|
|cellular response to chromate|
|regulation of granulosa cell apoptotic process|
|positive regulation of apoptotic process by virus|
|positive regulation by symbiont of host apoptotic process|
|positive regulation by symbiont of host programmed cell death|
|killing by symbiont of host cells|
|positive regulation by organism of programmed cell death in other organism involved in symbiotic interaction|
|suppression by virus of host apoptotic process|
|positive regulation of type B pancreatic cell development|
|cellular process regulating host cell cycle in response to virus|
|disruption by symbiont of host cell|
|negative regulation by symbiont of host programmed cell death|
|negative regulation by symbiont of host apoptotic process|
|modulation by virus of host apoptotic process|
|positive regulation of glucokinase activity|
|response to oleic acid|
|modulation of programmed cell death in other organism involved in symbiotic interaction|
|modulation of programmed cell death in other organism|
|modulation by symbiont of host apoptotic process|
|modulation of apoptotic process in other organism|
|positive regulation of hexokinase activity|
|protein insertion into mitochondrial membrane involved in apoptotic signaling pathway|
|modulation by organism of apoptotic process in other organism involved in symbiotic interaction|
|regulation of intrinsic apoptotic signaling pathway in response to osmotic stress|
|protein phosphatase 2B binding|
|regulation of type B pancreatic cell development|
|modulation by symbiont of host programmed cell death|
|cellular response to nicotine|
|type B pancreatic cell proliferation|
|positive regulation of mitochondrial membrane potential|
|regulation of cellular response to osmotic stress|
|regulation of glucokinase activity|
|protein kinase B binding|
|regulation of hexokinase activity|
|killing of cells in other organism involved in symbiotic interaction|
|positive regulation of B cell differentiation|
|disruption of cells of other organism involved in symbiotic interaction|
|regulation of response to osmotic stress|
|mitochondrial outer membrane permeabilization|
|positive regulation of killing of cells of other organism|
|activation of cysteine-type endopeptidase activity|
|positive regulation of membrane potential|
|positive regulation of mitochondrial membrane permeability involved in apoptotic process|
|cysteine-type endopeptidase activator activity involved in apoptotic process|
|regulation of killing of cells of other organism|
|mitochondrial outer membrane permeabilization involved in programmed cell death|
|modulation by virus of host cellular process|
|positive regulation of mitochondrial membrane permeability|
|protein insertion into mitochondrial membrane|
|pore complex assembly|
|release of cytochrome c from mitochondria|
|regulation of mitochondrial membrane permeability involved in apoptotic process|
|positive regulation of membrane permeability|
|modulation by symbiont of host cellular process|
|positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway|
|regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway|
|regulation of B cell differentiation|
|14-3-3 protein binding|
|positive regulation of release of cytochrome c from mitochondria|
|glucose catabolic process|
|signal transduction in absence of ligand|
|extrinsic apoptotic signaling pathway in absence of ligand|
|modulation by virus of host morphology or physiology|
|positive regulation of epithelial cell apoptotic process|
|cellular response to virus|
|positive regulation of insulin secretion involved in cellular response to glucose stimulus|
|extrinsic apoptotic signaling pathway via death domain receptors|
|positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway|
|protein insertion into membrane|
|response to testosterone|
|modification by symbiont of host morphology or physiology|
|zymogen activation|
|regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway|
|response to progesterone|
|regulation of release of cytochrome c from mitochondria|
|response to nicotine|
|disruption of cells of other organism|
|killing of cells of other organism|
|ADP metabolic process|
|hexose catabolic process|
|regulation of insulin secretion involved in cellular response to glucose stimulus|
|positive regulation of intrinsic apoptotic signaling pathway|
|positive regulation of establishment of protein localization to mitochondrion|
|positive regulation of cellular carbohydrate metabolic process|
|positive regulation of epithelial cell differentiation|
|apoptotic mitochondrial changes|
|monosaccharide catabolic process|
|purine ribonucleoside diphosphate metabolic process|
|purine nucleoside diphosphate metabolic process|
|ribonucleoside diphosphate metabolic process|
|positive regulation of cell killing|
|regulation of mitochondrial membrane potential|
|intrinsic apoptotic signaling pathway in response to DNA damage|
|establishment of protein localization to mitochondrion|
|regulation of mitochondrial membrane permeability|
|regulation of establishment of protein localization to mitochondrion|
|positive regulation of insulin secretion|
|protein localization to mitochondrion|
|regulation of epithelial cell apoptotic process|
|cellular response to mechanical stimulus|
|positive regulation of carbohydrate metabolic process|
|regulation of membrane permeability|
|nucleoside diphosphate metabolic process|
|positive regulation of T cell differentiation|
|response to fatty acid|
|protein phosphatase binding|
|epithelial cell proliferation|
|activation of cysteine-type endopeptidase activity involved in apoptotic process|
|cell killing|
|positive regulation of neuron death|
|positive regulation of lymphocyte differentiation|
|extrinsic apoptotic signaling pathway|
|positive regulation of peptide hormone secretion|
|regulation of cell killing|
|phospholipid binding|
|modification of morphology or physiology of other organism involved in symbiotic interaction|
|glucose metabolic process|
|regulation of glucose metabolic process|
|response to amino acid|
|positive regulation of mitochondrion organization|
|cerebral cortex development|
|response to hydrogen peroxide|
|carbohydrate catabolic process|
|positive regulation of autophagy|
|positive regulation of protein localization to membrane|
|response to ethanol|
|positive regulation of hormone secretion|
|mitochondrial membrane organization|
|positive regulation of cysteine-type endopeptidase activity involved in apoptotic process|
|response to estradiol|
|regulation of T cell differentiation|
|response to glucose|
|regulation of cellular carbohydrate metabolic process|
|regulation of epithelial cell differentiation|
|response to hexose|
|response to glucocorticoid|
|positive regulation of leukocyte differentiation|
|response to monosaccharide|
|intrinsic apoptotic signaling pathway|
|positive regulation of cysteine-type endopeptidase activity|
|response to calcium ion|
|lipid binding|
|modification of morphology or physiology of other organism|
|hexose metabolic process|
|interaction with host|
|protein processing|
|regulation of intrinsic apoptotic signaling pathway|
|response to corticosteroid|
|mitochondrial outer membrane|
|positive regulation of B cell activation|
|regulation of lymphocyte differentiation|
|response to carbohydrate|
|positive regulation of endopeptidase activity|
|pallium development|
|positive regulation of apoptotic signaling pathway|
|regulation of insulin secretion|
|regulation of mitochondrion organization|
|glucose homeostasis|
|carbohydrate homeostasis|
|cellular response to hypoxia|
|positive regulation of hemopoiesis|
|regulation of protein localization to membrane|
|positive regulation of epithelial cell proliferation|
|positive regulation of peptidase activity|
|response to ketone|
|response to reactive oxygen species|
|cellular response to decreased oxygen levels|
|monosaccharide metabolic process|
|positive regulation of T cell activation|
|ATP metabolic process|
|regulation of carbohydrate metabolic process|
|regulation of B cell activation|
|regulation of peptide hormone secretion|
|response to mechanical stimulus|
|cellular response to toxic substance|
|cellular response to oxygen levels|
|mitochondrial transport|
|regulation of cysteine-type endopeptidase activity involved in apoptotic process|
|positive regulation of leukocyte cell-cell adhesion|
|regulation of symbiosis, encompassing mutualism through parasitism|
|cellular response to inorganic substance|
|protein maturation|
|response to alcohol|
|regulation of cysteine-type endopeptidase activity|
|positive regulation of cell-cell adhesion|
|telencephalon development|
|establishment of protein localization to membrane|
|regulation of hormone secretion|
|positive regulation of protein secretion|
|regulation of leukocyte differentiation|
|response to virus|
|apoptotic signaling pathway|
|positive regulation of peptide secretion|
|regulation of leukocyte cell-cell adhesion|
|response to antibiotic|
|regulation of neuron death|
|purine ribonucleotide metabolic process|
|cellular response to abiotic stimulus|
|cellular response to environmental stimulus|
|regulation of T cell activation|
|positive regulation of cellular protein localization|
|ribonucleotide metabolic process|
|response to steroid hormone|
|purine nucleotide metabolic process|
|regulation of autophagy|
|regulation of epithelial cell proliferation|
|cellular response to external stimulus|
|ribose phosphate metabolic process|
|response to hypoxia|
|response to acid chemical|
|positive regulation of proteolysis|
|response to decreased oxygen levels|
|positive regulation of lymphocyte activation|
|positive regulation of cellular catabolic process|
|purine-containing compound metabolic process|
|response to metal ion|
|response to oxygen levels|
|response to oxidative stress|
|forebrain development|
|regulation of apoptotic signaling pathway|
|regulation of cell-cell adhesion|
|positive regulation of secretion by cell|
|positive regulation of cell adhesion|
|positive regulation of leukocyte activation|
|cellular response to drug|
|positive regulation of cell activation|
|regulation of endopeptidase activity|
|positive regulation of protein transport|
|regulation of small molecule metabolic process|
|regulation of membrane potential|
|establishment of protein localization to organelle|
|positive regulation of catabolic process|
|positive regulation of secretion|
|small molecule catabolic process|
|mitochondrion organization|
|regulation of peptidase activity|
|nucleotide metabolic process|
|nucleoside phosphate metabolic process|
|regulation of hemopoiesis|
|positive regulation of establishment of protein localization|
|protein kinase binding|
|regulation of protein secretion|
|carbohydrate metabolic process|
|protein localization to membrane|
|protein heterodimerization activity|
|regulation of peptide secretion|
|response to toxic substance|
|positive regulation of multi-organism process|
|regulation of lymphocyte activation|
|cellular response to lipid|
|regulation of hormone levels|
|response to inorganic substance|
|regulation of cellular protein localization|
|nucleobase-containing small molecule metabolic process|
|positive regulation of cell development|
|spermatogenesis|
|cell population proliferation|
|male gamete generation|
|positive regulation of kinase activity|
|regulation of leukocyte activation|
|positive regulation of organelle organization|
|regulation of cell activation|
|positive regulation of apoptotic process|
|positive regulation of programmed cell death|
|positive regulation of transferase activity|
|cytokine-mediated signaling pathway|
|regulation of cell adhesion|
|gamete generation|
|positive regulation of cell death|
|viral process|
|regulation of protein transport|
|regulation of proteolysis|
|regulation of cellular response to stress|
|protein localization to organelle|
|regulation of peptide transport|
|brain development|
|regulation of establishment of protein localization|
|regulation of secretion by cell|
|positive regulation of hydrolase activity|
|regulation of multi-organism process|
|cellular response to DNA damage stimulus|
|head development|
|symbiotic process|
|regulation of secretion|
|interspecies interaction between organisms|
|multicellular organismal reproductive process|
|sexual reproduction|
|regulation of cellular catabolic process|
|multicellular organism reproduction|
|membrane organization|
|response to lipid|
|regulation of kinase activity|
|organophosphate metabolic process|
|negative regulation of apoptotic process|
|negative regulation of programmed cell death|
|response to hormone|
|positive regulation of cell population proliferation|
|regulation of cellular localization|
|response to organic cyclic compound|
|apoptotic process|
|regulation of cell development|
|positive regulation of cell differentiation|
|regulation of transferase activity|
|central nervous system development|
|positive regulation of transport|
|regulation of catabolic process|
|negative regulation of cell death|
|multi-organism reproductive process|
|response to organonitrogen compound|
|cellular response to cytokine stimulus|
|positive regulation of intracellular signal transduction|
|response to drug|
|regulation of protein localization|
|carbohydrate derivative metabolic process|
|programmed cell death|
|cellular response to oxygen-containing compound|
|positive regulation of phosphorylation|
|response to nitrogen compound|
|cell death|
|response to cytokine|
|chemical homeostasis|
|positive regulation of phosphorus metabolic process|
|positive regulation of phosphate metabolic process|
|positive regulation of immune system process|
|response to abiotic stimulus|
|regulation of cell cycle|
|positive regulation of cellular component organization|
|mitochondrion|
|proteolysis|
|regulation of hydrolase activity|
|regulation of organelle organization|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|positive regulation of developmental process|
|reproductive process|
|reproduction|
|positive regulation of catalytic activity|
|response to endogenous stimulus|
|regulation of response to stress|
|regulation of apoptotic process|
|response to oxygen-containing compound|
|protein-containing complex assembly|
|regulation of programmed cell death|
|cellular protein localization|
|regulation of phosphorylation|
|cellular macromolecule localization|
|positive regulation of cellular protein metabolic process|
|establishment of protein localization|
|regulation of cell population proliferation|
|homeostatic process|
|regulation of immune system process|
|positive regulation of signal transduction|
|regulation of cell death|
|intracellular signal transduction|
|cellular response to stress|
|positive regulation of protein metabolic process|
|positive regulation of multicellular organismal process|
|small molecule metabolic process|
|organic substance catabolic process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|establishment of localization in cell|
|protein-containing complex subunit organization|
|regulation of transport|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp440|Aphidicolin 0.4μM R08 exp440]]|-2.06|
|[[:results:exp37|Wortmannin 0.5μM R00 exp37]]|1.75|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:s:scaf1|SCAF1]]|0.405|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 8329
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 2.97 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='BAD Expression in NALM6 Cells: 2.97'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>