BAD
Gene Information
- Official Symbol: BAD
- Official Name: BCL2 associated agonist of cell death
- Aliases and Previous Symbols: N/A
- Entrez ID: 572
- UniProt: Q92934
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Promotes cell death. Successfully competes for the binding to Bcl-X(L), Bcl-2 and Bcl-W, thereby affecting the level of heterodimerization of these proteins with BAX. Can reverse the death repressor activity of Bcl-X(L), but not that of Bcl-2 (By similarity). Appears to act as a link between growth factor receptor signaling and the apoptotic pathways. {ECO:0000250}.
Pfam Domains GO Terms
Pfam Domains
| Bcl-2 BAD |
GO Terms
| response to chromate |
| positive regulation of granulosa cell apoptotic process |
| positive regulation of intrinsic apoptotic signaling pathway in response to osmotic stress |
| cellular response to chromate |
| regulation of granulosa cell apoptotic process |
| positive regulation of apoptotic process by virus |
| positive regulation by symbiont of host apoptotic process |
| positive regulation by symbiont of host programmed cell death |
| killing by symbiont of host cells |
| positive regulation by organism of programmed cell death in other organism involved in symbiotic interaction |
| suppression by virus of host apoptotic process |
| positive regulation of type B pancreatic cell development |
| cellular process regulating host cell cycle in response to virus |
| disruption by symbiont of host cell |
| negative regulation by symbiont of host programmed cell death |
| negative regulation by symbiont of host apoptotic process |
| modulation by virus of host apoptotic process |
| positive regulation of glucokinase activity |
| response to oleic acid |
| modulation of programmed cell death in other organism involved in symbiotic interaction |
| modulation of programmed cell death in other organism |
| modulation by symbiont of host apoptotic process |
| modulation of apoptotic process in other organism |
| positive regulation of hexokinase activity |
| protein insertion into mitochondrial membrane involved in apoptotic signaling pathway |
| modulation by organism of apoptotic process in other organism involved in symbiotic interaction |
| regulation of intrinsic apoptotic signaling pathway in response to osmotic stress |
| protein phosphatase 2B binding |
| regulation of type B pancreatic cell development |
| modulation by symbiont of host programmed cell death |
| cellular response to nicotine |
| type B pancreatic cell proliferation |
| positive regulation of mitochondrial membrane potential |
| regulation of cellular response to osmotic stress |
| regulation of glucokinase activity |
| protein kinase B binding |
| regulation of hexokinase activity |
| killing of cells in other organism involved in symbiotic interaction |
| positive regulation of B cell differentiation |
| disruption of cells of other organism involved in symbiotic interaction |
| regulation of response to osmotic stress |
| mitochondrial outer membrane permeabilization |
| positive regulation of killing of cells of other organism |
| activation of cysteine-type endopeptidase activity |
| positive regulation of membrane potential |
| positive regulation of mitochondrial membrane permeability involved in apoptotic process |
| cysteine-type endopeptidase activator activity involved in apoptotic process |
| regulation of killing of cells of other organism |
| mitochondrial outer membrane permeabilization involved in programmed cell death |
| modulation by virus of host cellular process |
| positive regulation of mitochondrial membrane permeability |
| protein insertion into mitochondrial membrane |
| pore complex assembly |
| release of cytochrome c from mitochondria |
| regulation of mitochondrial membrane permeability involved in apoptotic process |
| positive regulation of membrane permeability |
| modulation by symbiont of host cellular process |
| positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway |
| regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway |
| regulation of B cell differentiation |
| 14-3-3 protein binding |
| positive regulation of release of cytochrome c from mitochondria |
| glucose catabolic process |
| signal transduction in absence of ligand |
| extrinsic apoptotic signaling pathway in absence of ligand |
| modulation by virus of host morphology or physiology |
| positive regulation of epithelial cell apoptotic process |
| cellular response to virus |
| positive regulation of insulin secretion involved in cellular response to glucose stimulus |
| extrinsic apoptotic signaling pathway via death domain receptors |
| positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway |
| protein insertion into membrane |
| response to testosterone |
| modification by symbiont of host morphology or physiology |
| zymogen activation |
| regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway |
| response to progesterone |
| regulation of release of cytochrome c from mitochondria |
| response to nicotine |
| disruption of cells of other organism |
| killing of cells of other organism |
| ADP metabolic process |
| hexose catabolic process |
| regulation of insulin secretion involved in cellular response to glucose stimulus |
| positive regulation of intrinsic apoptotic signaling pathway |
| positive regulation of establishment of protein localization to mitochondrion |
| positive regulation of cellular carbohydrate metabolic process |
| positive regulation of epithelial cell differentiation |
| apoptotic mitochondrial changes |
| monosaccharide catabolic process |
| purine ribonucleoside diphosphate metabolic process |
| purine nucleoside diphosphate metabolic process |
| ribonucleoside diphosphate metabolic process |
| positive regulation of cell killing |
| regulation of mitochondrial membrane potential |
| intrinsic apoptotic signaling pathway in response to DNA damage |
| establishment of protein localization to mitochondrion |
| regulation of mitochondrial membrane permeability |
| regulation of establishment of protein localization to mitochondrion |
| positive regulation of insulin secretion |
| protein localization to mitochondrion |
| regulation of epithelial cell apoptotic process |
| cellular response to mechanical stimulus |
| positive regulation of carbohydrate metabolic process |
| regulation of membrane permeability |
| nucleoside diphosphate metabolic process |
| positive regulation of T cell differentiation |
| response to fatty acid |
| protein phosphatase binding |
| epithelial cell proliferation |
| activation of cysteine-type endopeptidase activity involved in apoptotic process |
| cell killing |
| positive regulation of neuron death |
| positive regulation of lymphocyte differentiation |
| extrinsic apoptotic signaling pathway |
| positive regulation of peptide hormone secretion |
| regulation of cell killing |
| phospholipid binding |
| modification of morphology or physiology of other organism involved in symbiotic interaction |
| glucose metabolic process |
| regulation of glucose metabolic process |
| response to amino acid |
| positive regulation of mitochondrion organization |
| cerebral cortex development |
| response to hydrogen peroxide |
| carbohydrate catabolic process |
| positive regulation of autophagy |
| positive regulation of protein localization to membrane |
| response to ethanol |
| positive regulation of hormone secretion |
| mitochondrial membrane organization |
| positive regulation of cysteine-type endopeptidase activity involved in apoptotic process |
| response to estradiol |
| regulation of T cell differentiation |
| response to glucose |
| regulation of cellular carbohydrate metabolic process |
| regulation of epithelial cell differentiation |
| response to hexose |
| response to glucocorticoid |
| positive regulation of leukocyte differentiation |
| response to monosaccharide |
| intrinsic apoptotic signaling pathway |
| positive regulation of cysteine-type endopeptidase activity |
| response to calcium ion |
| lipid binding |
| modification of morphology or physiology of other organism |
| hexose metabolic process |
| interaction with host |
| protein processing |
| regulation of intrinsic apoptotic signaling pathway |
| response to corticosteroid |
| mitochondrial outer membrane |
| positive regulation of B cell activation |
| regulation of lymphocyte differentiation |
| response to carbohydrate |
| positive regulation of endopeptidase activity |
| pallium development |
| positive regulation of apoptotic signaling pathway |
| regulation of insulin secretion |
| regulation of mitochondrion organization |
| glucose homeostasis |
| carbohydrate homeostasis |
| cellular response to hypoxia |
| positive regulation of hemopoiesis |
| regulation of protein localization to membrane |
| positive regulation of epithelial cell proliferation |
| positive regulation of peptidase activity |
| response to ketone |
| response to reactive oxygen species |
| cellular response to decreased oxygen levels |
| monosaccharide metabolic process |
| positive regulation of T cell activation |
| ATP metabolic process |
| regulation of carbohydrate metabolic process |
| regulation of B cell activation |
| regulation of peptide hormone secretion |
| response to mechanical stimulus |
| cellular response to toxic substance |
| cellular response to oxygen levels |
| mitochondrial transport |
| regulation of cysteine-type endopeptidase activity involved in apoptotic process |
| positive regulation of leukocyte cell-cell adhesion |
| regulation of symbiosis, encompassing mutualism through parasitism |
| cellular response to inorganic substance |
| protein maturation |
| response to alcohol |
| regulation of cysteine-type endopeptidase activity |
| positive regulation of cell-cell adhesion |
| telencephalon development |
| establishment of protein localization to membrane |
| regulation of hormone secretion |
| positive regulation of protein secretion |
| regulation of leukocyte differentiation |
| response to virus |
| apoptotic signaling pathway |
| positive regulation of peptide secretion |
| regulation of leukocyte cell-cell adhesion |
| response to antibiotic |
| regulation of neuron death |
| purine ribonucleotide metabolic process |
| cellular response to abiotic stimulus |
| cellular response to environmental stimulus |
| regulation of T cell activation |
| positive regulation of cellular protein localization |
| ribonucleotide metabolic process |
| response to steroid hormone |
| purine nucleotide metabolic process |
| regulation of autophagy |
| regulation of epithelial cell proliferation |
| cellular response to external stimulus |
| ribose phosphate metabolic process |
| response to hypoxia |
| response to acid chemical |
| positive regulation of proteolysis |
| response to decreased oxygen levels |
| positive regulation of lymphocyte activation |
| positive regulation of cellular catabolic process |
| purine-containing compound metabolic process |
| response to metal ion |
| response to oxygen levels |
| response to oxidative stress |
| forebrain development |
| regulation of apoptotic signaling pathway |
| regulation of cell-cell adhesion |
| positive regulation of secretion by cell |
| positive regulation of cell adhesion |
| positive regulation of leukocyte activation |
| cellular response to drug |
| positive regulation of cell activation |
| regulation of endopeptidase activity |
| positive regulation of protein transport |
| regulation of small molecule metabolic process |
| regulation of membrane potential |
| establishment of protein localization to organelle |
| positive regulation of catabolic process |
| positive regulation of secretion |
| small molecule catabolic process |
| mitochondrion organization |
| regulation of peptidase activity |
| nucleotide metabolic process |
| nucleoside phosphate metabolic process |
| regulation of hemopoiesis |
| positive regulation of establishment of protein localization |
| protein kinase binding |
| regulation of protein secretion |
| carbohydrate metabolic process |
| protein localization to membrane |
| protein heterodimerization activity |
| regulation of peptide secretion |
| response to toxic substance |
| positive regulation of multi-organism process |
| regulation of lymphocyte activation |
| cellular response to lipid |
| regulation of hormone levels |
| response to inorganic substance |
| regulation of cellular protein localization |
| nucleobase-containing small molecule metabolic process |
| positive regulation of cell development |
| spermatogenesis |
| cell population proliferation |
| male gamete generation |
| positive regulation of kinase activity |
| regulation of leukocyte activation |
| positive regulation of organelle organization |
| regulation of cell activation |
| positive regulation of apoptotic process |
| positive regulation of programmed cell death |
| positive regulation of transferase activity |
| cytokine-mediated signaling pathway |
| regulation of cell adhesion |
| gamete generation |
| positive regulation of cell death |
| viral process |
| regulation of protein transport |
| regulation of proteolysis |
| regulation of cellular response to stress |
| protein localization to organelle |
| regulation of peptide transport |
| brain development |
| regulation of establishment of protein localization |
| regulation of secretion by cell |
| positive regulation of hydrolase activity |
| regulation of multi-organism process |
| cellular response to DNA damage stimulus |
| head development |
| symbiotic process |
| regulation of secretion |
| interspecies interaction between organisms |
| multicellular organismal reproductive process |
| sexual reproduction |
| regulation of cellular catabolic process |
| multicellular organism reproduction |
| membrane organization |
| response to lipid |
| regulation of kinase activity |
| organophosphate metabolic process |
| negative regulation of apoptotic process |
| negative regulation of programmed cell death |
| response to hormone |
| positive regulation of cell population proliferation |
| regulation of cellular localization |
| response to organic cyclic compound |
| apoptotic process |
| regulation of cell development |
| positive regulation of cell differentiation |
| regulation of transferase activity |
| central nervous system development |
| positive regulation of transport |
| regulation of catabolic process |
| negative regulation of cell death |
| multi-organism reproductive process |
| response to organonitrogen compound |
| cellular response to cytokine stimulus |
| positive regulation of intracellular signal transduction |
| response to drug |
| regulation of protein localization |
| carbohydrate derivative metabolic process |
| programmed cell death |
| cellular response to oxygen-containing compound |
| positive regulation of phosphorylation |
| response to nitrogen compound |
| cell death |
| response to cytokine |
| chemical homeostasis |
| positive regulation of phosphorus metabolic process |
| positive regulation of phosphate metabolic process |
| positive regulation of immune system process |
| response to abiotic stimulus |
| regulation of cell cycle |
| positive regulation of cellular component organization |
| mitochondrion |
| proteolysis |
| regulation of hydrolase activity |
| regulation of organelle organization |
| response to other organism |
| response to external biotic stimulus |
| response to biotic stimulus |
| positive regulation of developmental process |
| reproductive process |
| reproduction |
| positive regulation of catalytic activity |
| response to endogenous stimulus |
| regulation of response to stress |
| regulation of apoptotic process |
| response to oxygen-containing compound |
| protein-containing complex assembly |
| regulation of programmed cell death |
| cellular protein localization |
| regulation of phosphorylation |
| cellular macromolecule localization |
| positive regulation of cellular protein metabolic process |
| establishment of protein localization |
| regulation of cell population proliferation |
| homeostatic process |
| regulation of immune system process |
| positive regulation of signal transduction |
| regulation of cell death |
| intracellular signal transduction |
| cellular response to stress |
| positive regulation of protein metabolic process |
| positive regulation of multicellular organismal process |
| small molecule metabolic process |
| organic substance catabolic process |
| positive regulation of molecular function |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| regulation of cell differentiation |
| positive regulation of cell communication |
| positive regulation of signaling |
| regulation of intracellular signal transduction |
| establishment of localization in cell |
| protein-containing complex subunit organization |
| regulation of transport |
| gene expression |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| Aphidicolin 0.4μM R08 exp440 | -2.06 |
| Wortmannin 0.5μM R00 exp37 | 1.75 |
Most Correlated Genes in Chemogenomics
| Gene | Correlation |
|---|---|
| SCAF1 | 0.405 |
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 8329
- Expression level (log2 read counts): 2.97
Expression Distribution
BAD Expression in NALM6 Cells: 2.97
