BAG2 [The Human Chemical-Genetic Interaction Map Project]

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======= BAG2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: BAG2
  * **<color #00a2e8>Official Name</color>**: BAG cochaperone 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=9532|9532]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O95816|O95816]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=BAG2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20BAG2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603882|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Co-chaperone for HSP70 and HSC70 chaperone proteins. Acts as a nucleotide-exchange factor (NEF) promoting the release of ADP from the HSP70 and HSC70 proteins thereby triggering client/substrate protein release (PubMed:24318877, PubMed:9873016). {ECO:0000269|PubMed:24318877, ECO:0000269|PubMed:9873016}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|BAG|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|dendritic microtubule|
|negative regulation of ubiquitin protein ligase activity|
|adenyl-nucleotide exchange factor activity|
|chaperone complex|
|negative regulation of ubiquitin-protein transferase activity|
|regulation of ubiquitin protein ligase activity|
|positive regulation of protein processing|
|positive regulation of protein maturation|
|tau protein binding|
|regulation of ubiquitin-protein transferase activity|
|heat shock protein binding|
|regulation of protein processing|
|regulation of protein maturation|
|negative regulation of protein ubiquitination|
|regulation of cellular response to heat|
|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|
|negative regulation of protein modification by small protein conjugation or removal|
|positive regulation of ubiquitin-dependent protein catabolic process|
|negative regulation of protein binding|
|chaperone binding|
|positive regulation of proteasomal protein catabolic process|
|positive regulation of proteolysis involved in cellular protein catabolic process|
|regulation of proteasomal ubiquitin-dependent protein catabolic process|
|ion channel binding|
|positive regulation of cellular protein catabolic process|
|regulation of ubiquitin-dependent protein catabolic process|
|negative regulation of binding|
|protein stabilization|
|regulation of proteasomal protein catabolic process|
|regulation of protein ubiquitination|
|regulation of proteolysis involved in cellular protein catabolic process|
|positive regulation of protein catabolic process|
|regulation of protein binding|
|regulation of protein modification by small protein conjugation or removal|
|protein folding|
|regulation of cellular protein catabolic process|
|negative regulation of transferase activity|
|regulation of protein stability|
|ubiquitin protein ligase binding|
|axon|
|microtubule|
|positive regulation of proteolysis|
|positive regulation of cellular catabolic process|
|regulation of binding|
|regulation of protein catabolic process|
|dendrite|
|positive regulation of catabolic process|
|negative regulation of protein modification process|
|regulation of proteolysis|
|regulation of cellular response to stress|
|negative regulation of catalytic activity|
|regulation of cellular catabolic process|
|regulation of transferase activity|
|regulation of catabolic process|
|negative regulation of cellular protein metabolic process|
|identical protein binding|
|negative regulation of protein metabolic process|
|negative regulation of molecular function|
|regulation of response to stress|
|positive regulation of cellular protein metabolic process|
|positive regulation of protein metabolic process|
|regulation of protein modification process|
|positive regulation of gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp24|Nocodazole 0.2μM R00 exp24]]|-2.37|
|[[:results:exp299|Talazoparib 0.006μM R06 exp299]]|-2.26|
|[[:results:exp16|DABN 2μM R00 exp16]]|-1.74|
|[[:results:exp27|Pimelic-diphenylamide-106 0.5μM R00 exp27]]|-1.74|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 18824
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.15 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='BAG2 Expression in NALM6 Cells: 5.15'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>