BAG2

Gene Information

Official Symbol: BAG2
Official Name: BAG cochaperone 2
Aliases and Previous Symbols: N/A
Entrez ID: 9532
UniProt: O95816
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Co-chaperone for HSP70 and HSC70 chaperone proteins. Acts as a nucleotide-exchange factor (NEF) promoting the release of ADP from the HSP70 and HSC70 proteins thereby triggering client/substrate protein release (PubMed:24318877, PubMed:9873016). {ECO:0000269|PubMed:24318877, ECO:0000269|PubMed:9873016}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 18824
Expression level (log2 read counts): 5.15

Expression Distribution

Screen	Score
Nocodazole 0.2μM R00 exp24	-2.37
Talazoparib 0.006μM R06 exp299	-2.26
DABN 2μM R00 exp16	-1.74
Pimelic-diphenylamide-106 0.5μM R00 exp27	-1.74

dendritic microtubule
negative regulation of ubiquitin protein ligase activity
adenyl-nucleotide exchange factor activity
chaperone complex
negative regulation of ubiquitin-protein transferase activity
regulation of ubiquitin protein ligase activity
positive regulation of protein processing
positive regulation of protein maturation
tau protein binding
regulation of ubiquitin-protein transferase activity
heat shock protein binding
regulation of protein processing
regulation of protein maturation
negative regulation of protein ubiquitination
regulation of cellular response to heat
positive regulation of proteasomal ubiquitin-dependent protein catabolic process
negative regulation of protein modification by small protein conjugation or removal
positive regulation of ubiquitin-dependent protein catabolic process
negative regulation of protein binding
chaperone binding
positive regulation of proteasomal protein catabolic process
positive regulation of proteolysis involved in cellular protein catabolic process
regulation of proteasomal ubiquitin-dependent protein catabolic process
ion channel binding
positive regulation of cellular protein catabolic process
regulation of ubiquitin-dependent protein catabolic process
negative regulation of binding
protein stabilization
regulation of proteasomal protein catabolic process
regulation of protein ubiquitination
regulation of proteolysis involved in cellular protein catabolic process
positive regulation of protein catabolic process
regulation of protein binding
regulation of protein modification by small protein conjugation or removal
protein folding
regulation of cellular protein catabolic process
negative regulation of transferase activity
regulation of protein stability
ubiquitin protein ligase binding
axon