BAG4 [The Human Chemical-Genetic Interaction Map Project]

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======= BAG4 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: BAG4
  * **<color #00a2e8>Official Name</color>**: BAG cochaperone 4
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=9530|9530]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O95429|O95429]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=BAG4&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20BAG4|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603884|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release (By similarity). Prevents constitutive TNFRSF1A signaling. Negative regulator of PRKN translocation to damaged mitochondria. {ECO:0000250, ECO:0000269|PubMed:24270810}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|BAG|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity|
|regulation of phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity|
|negative regulation of protein targeting to mitochondrion|
|negative regulation of establishment of protein localization to mitochondrion|
|ruffle assembly|
|positive regulation of fibroblast migration|
|ruffle organization|
|regulation of fibroblast migration|
|negative regulation of intracellular protein transport|
|cellular response to epidermal growth factor stimulus|
|regulation of protein targeting to mitochondrion|
|response to epidermal growth factor|
|positive regulation of stress fiber assembly|
|negative regulation of mitochondrion organization|
|negative regulation of intracellular transport|
|positive regulation of actin filament bundle assembly|
|regulation of establishment of protein localization to mitochondrion|
|regulation of stress fiber assembly|
|regulation of cellular response to heat|
|regulation of protein targeting|
|regulation of actomyosin structure organization|
|positive regulation of actin filament polymerization|
|regulation of actin filament bundle assembly|
|chaperone binding|
|positive regulation of peptidyl-serine phosphorylation|
|negative regulation of phosphatase activity|
|negative regulation of dephosphorylation|
|negative regulation of cellular protein localization|
|tumor necrosis factor-mediated signaling pathway|
|positive regulation of protein polymerization|
|regulation of peptidyl-serine phosphorylation|
|regulation of actin filament polymerization|
|positive regulation of protein kinase B signaling|
|regulation of phosphatase activity|
|regulation of mitochondrion organization|
|negative regulation of protein transport|
|regulation of actin polymerization or depolymerization|
|regulation of actin filament length|
|protein localization to plasma membrane|
|negative regulation of establishment of protein localization|
|positive regulation of supramolecular fiber organization|
|regulation of dephosphorylation|
|positive regulation of cytoskeleton organization|
|regulation of protein kinase B signaling|
|regulation of protein polymerization|
|protein localization to cell periphery|
|regulation of intracellular protein transport|
|protein folding|
|cellular response to tumor necrosis factor|
|positive regulation of protein complex assembly|
|regulation of actin filament organization|
|response to tumor necrosis factor|
|ubiquitin protein ligase binding|
|regulation of actin cytoskeleton organization|
|regulation of intracellular transport|
|regulation of supramolecular fiber organization|
|negative regulation of organelle organization|
|regulation of cellular component size|
|regulation of actin filament-based process|
|positive regulation of cell adhesion|
|plasma membrane bounded cell projection assembly|
|regulation of protein complex assembly|
|negative regulation of hydrolase activity|
|cell projection assembly|
|protein localization to membrane|
|negative regulation of transport|
|cellular response to growth factor stimulus|
|positive regulation of cell migration|
|regulation of anatomical structure size|
|positive regulation of cellular component biogenesis|
|positive regulation of cell motility|
|response to growth factor|
|positive regulation of cellular component movement|
|regulation of cellular protein localization|
|regulation of cytoskeleton organization|
|positive regulation of locomotion|
|negative regulation of phosphate metabolic process|
|negative regulation of phosphorus metabolic process|
|positive regulation of organelle organization|
|cytokine-mediated signaling pathway|
|regulation of cell adhesion|
|negative regulation of cellular component organization|
|regulation of protein transport|
|regulation of cellular response to stress|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|negative regulation of catalytic activity|
|regulation of cell migration|
|negative regulation of apoptotic process|
|negative regulation of programmed cell death|
|regulation of cell motility|
|regulation of cellular localization|
|regulation of cellular component biogenesis|
|regulation of locomotion|
|negative regulation of cell death|
|regulation of cellular component movement|
|cellular response to cytokine stimulus|
|positive regulation of protein phosphorylation|
|positive regulation of intracellular signal transduction|
|regulation of protein localization|
|positive regulation of phosphorylation|
|response to cytokine|
|plasma membrane bounded cell projection organization|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|negative regulation of molecular function|
|cell projection organization|
|positive regulation of cellular component organization|
|cellular response to endogenous stimulus|
|positive regulation of protein modification process|
|regulation of hydrolase activity|
|regulation of organelle organization|
|RNA binding|
|regulation of protein phosphorylation|
|response to endogenous stimulus|
|regulation of response to stress|
|regulation of apoptotic process|
|regulation of programmed cell death|
|cellular protein localization|
|regulation of phosphorylation|
|cellular macromolecule localization|
|positive regulation of cellular protein metabolic process|
|positive regulation of signal transduction|
|regulation of cell death|
|positive regulation of protein metabolic process|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|regulation of transport|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 6814
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.06 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='BAG4 Expression in NALM6 Cells: 5.06'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>