BAG4
Gene Information
- Official Symbol: BAG4
- Official Name: BAG cochaperone 4
- Aliases and Previous Symbols: N/A
- Entrez ID: 9530
- UniProt: O95429
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release (By similarity). Prevents constitutive TNFRSF1A signaling. Negative regulator of PRKN translocation to damaged mitochondria. {ECO:0000250, ECO:0000269|PubMed:24270810}.
Pfam Domains GO Terms
Pfam Domains
| BAG |
GO Terms
| negative regulation of phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity |
| regulation of phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity |
| negative regulation of protein targeting to mitochondrion |
| negative regulation of establishment of protein localization to mitochondrion |
| ruffle assembly |
| positive regulation of fibroblast migration |
| ruffle organization |
| regulation of fibroblast migration |
| negative regulation of intracellular protein transport |
| cellular response to epidermal growth factor stimulus |
| regulation of protein targeting to mitochondrion |
| response to epidermal growth factor |
| positive regulation of stress fiber assembly |
| negative regulation of mitochondrion organization |
| negative regulation of intracellular transport |
| positive regulation of actin filament bundle assembly |
| regulation of establishment of protein localization to mitochondrion |
| regulation of stress fiber assembly |
| regulation of cellular response to heat |
| regulation of protein targeting |
| regulation of actomyosin structure organization |
| positive regulation of actin filament polymerization |
| regulation of actin filament bundle assembly |
| chaperone binding |
| positive regulation of peptidyl-serine phosphorylation |
| negative regulation of phosphatase activity |
| negative regulation of dephosphorylation |
| negative regulation of cellular protein localization |
| tumor necrosis factor-mediated signaling pathway |
| positive regulation of protein polymerization |
| regulation of peptidyl-serine phosphorylation |
| regulation of actin filament polymerization |
| positive regulation of protein kinase B signaling |
| regulation of phosphatase activity |
| regulation of mitochondrion organization |
| negative regulation of protein transport |
| regulation of actin polymerization or depolymerization |
| regulation of actin filament length |
| protein localization to plasma membrane |
| negative regulation of establishment of protein localization |
| positive regulation of supramolecular fiber organization |
| regulation of dephosphorylation |
| positive regulation of cytoskeleton organization |
| regulation of protein kinase B signaling |
| regulation of protein polymerization |
| protein localization to cell periphery |
| regulation of intracellular protein transport |
| protein folding |
| cellular response to tumor necrosis factor |
| positive regulation of protein complex assembly |
| regulation of actin filament organization |
| response to tumor necrosis factor |
| ubiquitin protein ligase binding |
| regulation of actin cytoskeleton organization |
| regulation of intracellular transport |
| regulation of supramolecular fiber organization |
| negative regulation of organelle organization |
| regulation of cellular component size |
| regulation of actin filament-based process |
| positive regulation of cell adhesion |
| plasma membrane bounded cell projection assembly |
| regulation of protein complex assembly |
| negative regulation of hydrolase activity |
| cell projection assembly |
| protein localization to membrane |
| negative regulation of transport |
| cellular response to growth factor stimulus |
| positive regulation of cell migration |
| regulation of anatomical structure size |
| positive regulation of cellular component biogenesis |
| positive regulation of cell motility |
| response to growth factor |
| positive regulation of cellular component movement |
| regulation of cellular protein localization |
| regulation of cytoskeleton organization |
| positive regulation of locomotion |
| negative regulation of phosphate metabolic process |
| negative regulation of phosphorus metabolic process |
| positive regulation of organelle organization |
| cytokine-mediated signaling pathway |
| regulation of cell adhesion |
| negative regulation of cellular component organization |
| regulation of protein transport |
| regulation of cellular response to stress |
| regulation of peptide transport |
| regulation of establishment of protein localization |
| negative regulation of catalytic activity |
| regulation of cell migration |
| negative regulation of apoptotic process |
| negative regulation of programmed cell death |
| regulation of cell motility |
| regulation of cellular localization |
| regulation of cellular component biogenesis |
| regulation of locomotion |
| negative regulation of cell death |
| regulation of cellular component movement |
| cellular response to cytokine stimulus |
| positive regulation of protein phosphorylation |
| positive regulation of intracellular signal transduction |
| regulation of protein localization |
| positive regulation of phosphorylation |
| response to cytokine |
| plasma membrane bounded cell projection organization |
| positive regulation of phosphate metabolic process |
| positive regulation of phosphorus metabolic process |
| negative regulation of molecular function |
| cell projection organization |
| positive regulation of cellular component organization |
| cellular response to endogenous stimulus |
| positive regulation of protein modification process |
| regulation of hydrolase activity |
| regulation of organelle organization |
| RNA binding |
| regulation of protein phosphorylation |
| response to endogenous stimulus |
| regulation of response to stress |
| regulation of apoptotic process |
| regulation of programmed cell death |
| cellular protein localization |
| regulation of phosphorylation |
| cellular macromolecule localization |
| positive regulation of cellular protein metabolic process |
| positive regulation of signal transduction |
| regulation of cell death |
| positive regulation of protein metabolic process |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| positive regulation of cell communication |
| positive regulation of signaling |
| regulation of intracellular signal transduction |
| regulation of protein modification process |
| regulation of transport |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
No hits were found.
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 6814
- Expression level (log2 read counts): 5.06
Expression Distribution
BAG4 Expression in NALM6 Cells: 5.06
