BAG5

Gene Information

Official Symbol: BAG5
Official Name: BAG cochaperone 5
Aliases and Previous Symbols: N/A
Entrez ID: 9529
UniProt: Q9UL15
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Inhibits both auto-ubiquitination of PRKN and ubiquitination of target proteins by PRKN (By similarity). May function as a nucleotide exchange factor for HSP/HSP70, promoting ADP release, and activating Hsp70-mediated refolding. {ECO:0000250, ECO:0000269|PubMed:20223214}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 17440
Expression level (log2 read counts): 6.61

Expression Distribution

regulation of protein refolding
negative regulation of protein refolding
negative regulation of protein folding
regulation of protein folding
negative regulation of ubiquitin-protein transferase activity
regulation of inclusion body assembly
inclusion body
negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
negative regulation of proteasomal ubiquitin-dependent protein catabolic process
negative regulation of cellular response to oxidative stress
negative regulation of oxidative stress-induced cell death
negative regulation of response to oxidative stress
negative regulation of ubiquitin-dependent protein catabolic process
regulation of ubiquitin-protein transferase activity
neuron death
negative regulation of proteasomal protein catabolic process
regulation of oxidative stress-induced cell death
negative regulation of proteolysis involved in cellular protein catabolic process
negative regulation of protein ubiquitination
regulation of cellular response to oxidative stress
regulation of cellular response to heat
negative regulation of protein modification by small protein conjugation or removal
regulation of response to oxidative stress
negative regulation of cellular protein catabolic process
negative regulation of intrinsic apoptotic signaling pathway
chaperone binding
regulation of proteasomal ubiquitin-dependent protein catabolic process
Golgi organization
negative regulation of protein catabolic process
regulation of ubiquitin-dependent protein catabolic process
negative regulation of neuron projection development
regulation of intrinsic apoptotic signaling pathway
protein stabilization
negative regulation of cell projection organization
regulation of proteasomal protein catabolic process
regulation of protein ubiquitination
regulation of proteolysis involved in cellular protein catabolic process
negative regulation of apoptotic signaling pathway
negative regulation of neuron differentiation