BAI2

Entrez Summary: N/A
UniProt Summary: Orphan G-protein coupled receptor involved in cell adhesion and probably in cell-cell interactions. Activates NFAT- signaling pathway, a transcription factor, via the G-protein GNAZ (PubMed:20367554, PubMed:28891236). Involved in angiogenesis inhibition (By similarity). {ECO:0000250|UniProtKB:Q8CGM1, ECO:0000269|PubMed:20367554, ECO:0000269|PubMed:28891236}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

calcineurin-NFAT signaling cascade
calcineurin-mediated signaling
inositol phosphate-mediated signaling
positive regulation of synapse assembly
peripheral nervous system development
negative regulation of angiogenesis
negative regulation of blood vessel morphogenesis
regulation of synapse assembly
negative regulation of vasculature development
adenylate cyclase-activating G protein-coupled receptor signaling pathway
calcium-mediated signaling
cAMP-mediated signaling
cyclic-nucleotide-mediated signaling
adenylate cyclase-modulating G protein-coupled receptor signaling pathway
regulation of synapse organization
regulation of synapse structure or activity
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
regulation of angiogenesis
regulation of vasculature development
second-messenger-mediated signaling
centrosome
positive regulation of cellular component biogenesis
positive regulation of nervous system development
G protein-coupled receptor activity
regulation of nervous system development
negative regulation of developmental process
regulation of cellular component biogenesis
regulation of anatomical structure morphogenesis
negative regulation of multicellular organismal process
positive regulation of cellular component organization
G protein-coupled receptor signaling pathway
positive regulation of developmental process
integral component of plasma membrane
intracellular signal transduction
positive regulation of multicellular organismal process