BAI3 [The Human Chemical-Genetic Interaction Map Project]

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======= BAI3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ADGRB3
  * **<color #00a2e8>Official Name</color>**: adhesion G protein-coupled receptor B3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=577|577]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O60242|O60242]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=BAI3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20BAI3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602684|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Receptor that plays a role in the regulation of synaptogenesis and dendritic spine formation at least partly via interaction with ELMO1 and RAC1 activity (By similarity). Promotes myoblast fusion through ELMO/DOCK1 (PubMed:24567399). {ECO:0000250|UniProtKB:O60242, ECO:0000269|PubMed:24567399}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|GPS|
|DUF3497|
|7tm 2|
|TSP 1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|motor learning|
|neuron remodeling|
|synaptic cleft|
|maintenance of synapse structure|
|myoblast fusion|
|syncytium formation by plasma membrane fusion|
|cell-cell fusion|
|syncytium formation|
|neuron maturation|
|cellular component maintenance|
|myotube differentiation|
|positive regulation of synapse assembly|
|postsynapse|
|regulation of dendrite morphogenesis|
|negative regulation of angiogenesis|
|negative regulation of blood vessel morphogenesis|
|regulation of synapse assembly|
|negative regulation of vasculature development|
|adenylate cyclase-activating G protein-coupled receptor signaling pathway|
|anatomical structure maturation|
|learning|
|cAMP-mediated signaling|
|regulation of dendrite development|
|cell maturation|
|cyclic-nucleotide-mediated signaling|
|striated muscle cell differentiation|
|adenylate cyclase-modulating G protein-coupled receptor signaling pathway|
|regulation of synapse organization|
|regulation of synapse structure or activity|
|developmental maturation|
|muscle cell differentiation|
|G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger|
|learning or memory|
|synapse organization|
|GTPase activator activity|
|regulation of angiogenesis|
|cognition|
|regulation of cell morphogenesis involved in differentiation|
|regulation of vasculature development|
|second-messenger-mediated signaling|
|positive regulation of GTPase activity|
|muscle structure development|
|regulation of GTPase activity|
|regulation of cell morphogenesis|
|regulation of neuron projection development|
|positive regulation of cellular component biogenesis|
|positive regulation of nervous system development|
|behavior|
|regulation of neuron differentiation|
|regulation of plasma membrane bounded cell projection organization|
|regulation of cell projection organization|
|G protein-coupled receptor activity|
|positive regulation of hydrolase activity|
|neuron development|
|regulation of neurogenesis|
|anatomical structure formation involved in morphogenesis|
|regulation of nervous system development|
|regulation of cell development|
|negative regulation of developmental process|
|regulation of cellular component biogenesis|
|neuron differentiation|
|regulation of anatomical structure morphogenesis|
|negative regulation of multicellular organismal process|
|positive regulation of cellular component organization|
|regulation of hydrolase activity|
|G protein-coupled receptor signaling pathway|
|positive regulation of developmental process|
|nervous system process|
|integral component of plasma membrane|
|positive regulation of catalytic activity|
|generation of neurons|
|neurogenesis|
|cell development|
|intracellular signal transduction|
|positive regulation of multicellular organismal process|
|positive regulation of molecular function|
|regulation of cell differentiation|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp70|INK128 0.2μM R02 exp70]]|1.77|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 14612
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -4.27 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='BAI3 Expression in NALM6 Cells: -4.27'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>