BAI3

Entrez Summary: N/A
UniProt Summary: Receptor that plays a role in the regulation of synaptogenesis and dendritic spine formation at least partly via interaction with ELMO1 and RAC1 activity (By similarity). Promotes myoblast fusion through ELMO/DOCK1 (PubMed:24567399). {ECO:0000250|UniProtKB:O60242, ECO:0000269|PubMed:24567399}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

motor learning
neuron remodeling
synaptic cleft
maintenance of synapse structure
myoblast fusion
syncytium formation by plasma membrane fusion
cell-cell fusion
syncytium formation
neuron maturation
cellular component maintenance
myotube differentiation
positive regulation of synapse assembly
postsynapse
regulation of dendrite morphogenesis
negative regulation of angiogenesis
negative regulation of blood vessel morphogenesis
regulation of synapse assembly
negative regulation of vasculature development
adenylate cyclase-activating G protein-coupled receptor signaling pathway
anatomical structure maturation
learning
cAMP-mediated signaling
regulation of dendrite development
cell maturation
cyclic-nucleotide-mediated signaling
striated muscle cell differentiation
adenylate cyclase-modulating G protein-coupled receptor signaling pathway
regulation of synapse organization
regulation of synapse structure or activity
developmental maturation
muscle cell differentiation
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
learning or memory
synapse organization
GTPase activator activity
regulation of angiogenesis
cognition
regulation of cell morphogenesis involved in differentiation
regulation of vasculature development
second-messenger-mediated signaling