BAZ2A [The Human Chemical-Genetic Interaction Map Project]

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======= BAZ2A =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: BAZ2A
  * **<color #00a2e8>Official Name</color>**: bromodomain adjacent to zinc finger domain 2A
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=11176|11176]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9UIF9|Q9UIF9]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=BAZ2A&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20BAZ2A|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605682|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Essential component of the NoRC (nucleolar remodeling complex) complex, a complex that mediates silencing of a fraction of rDNA by recruiting histone-modifying enzymes and DNA methyltransferases, leading to heterochromatin formation and transcriptional silencing. In the complex, it plays a central role by being recruited to rDNA and by targeting chromatin modifying enzymes such as HDAC1, leading to repress RNA polymerase I transcription. Recruited to rDNA via its interaction with TTF1 and its ability to recognize and bind histone H4 acetylated on 'Lys- 16' (H4K16ac), leading to deacetylation of H4K5ac, H4K8ac, H4K12ac but not H4K16ac. Specifically binds pRNAs, 150-250 nucleotide RNAs that are complementary in sequence to the rDNA promoter; pRNA- binding is required for heterochromatin formation and rDNA silencing (By similarity). {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|MBD|
|PHD|
|DDT|
|Bromodomain|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|rDNA heterochromatin|
|chromatin silencing complex|
|RNA polymerase I CORE element sequence-specific DNA binding|
|RNA polymerase I preinitiation complex assembly|
|chromatin silencing at rDNA|
|lysine-acetylated histone binding|
|nuclear receptor binding|
|transcription preinitiation complex assembly|
|transcription initiation from RNA polymerase I promoter|
|transcription by RNA polymerase I|
|DNA alkylation|
|DNA methylation|
|histone deacetylation|
|protein deacetylation|
|chromatin organization involved in negative regulation of transcription|
|chromatin silencing|
|protein deacylation|
|macromolecule deacylation|
|DNA methylation or demethylation|
|chromatin organization involved in regulation of transcription|
|negative regulation of gene expression, epigenetic|
|DNA modification|
|histone binding|
|gene silencing|
|chromatin remodeling|
|protein-DNA complex assembly|
|DNA-templated transcription, initiation|
|regulation of gene expression, epigenetic|
|protein-DNA complex subunit organization|
|macromolecule methylation|
|methylation|
|histone modification|
|covalent chromatin modification|
|nuclear speck|
|transcription, DNA-templated|
|nucleic acid-templated transcription|
|RNA biosynthetic process|
|chromatin organization|
|DNA metabolic process|
|cellular protein-containing complex assembly|
|nucleolus|
|chromosome organization|
|nucleobase-containing compound biosynthetic process|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|negative regulation of transcription, DNA-templated|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|organic cyclic compound biosynthetic process|
|negative regulation of RNA metabolic process|
|negative regulation of cellular macromolecule biosynthetic process|
|RNA binding|
|negative regulation of nucleobase-containing compound metabolic process|
|negative regulation of macromolecule biosynthetic process|
|negative regulation of cellular biosynthetic process|
|negative regulation of biosynthetic process|
|protein-containing complex assembly|
|cellular nitrogen compound biosynthetic process|
|RNA metabolic process|
|cellular macromolecule biosynthetic process|
|negative regulation of gene expression|
|macromolecule biosynthetic process|
|protein-containing complex subunit organization|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp502|Milciclib 2μM R08 exp502]]|-2.06|
|[[:results:exp80|RO-3307 4.7μM R02 exp80]]|-1.89|
|[[:results:exp451|Atovaquone 15μM R08 exp451]]|-1.8|
|[[:results:exp318|ABT-702 5μM R07 exp318]]|-1.73|
|[[:results:exp242|Radicicol 0.16μM R05 exp242]]|1.75|
|[[:results:exp316|Geldanamycin 0.015 to 0.025μM on day4 R07 exp316]]|1.82|
|[[:results:exp160|Ribavirin 10 to 15μM on day4 R04 exp160]]|1.89|
|[[:results:exp123|GSK-LSD1 10μM R03 exp123]]|1.95|
|[[:results:exp480|ETC-159 50μM R08 exp480]]|2.25|
|[[:results:exp243|S-trityl-L-cysteine 0.5μM R05 exp243]]|2.38|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/25|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 3055
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.12 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='BAZ2A Expression in NALM6 Cells: 7.12'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>