BAZ2A

Entrez Summary: N/A
UniProt Summary: Essential component of the NoRC (nucleolar remodeling complex) complex, a complex that mediates silencing of a fraction of rDNA by recruiting histone-modifying enzymes and DNA methyltransferases, leading to heterochromatin formation and transcriptional silencing. In the complex, it plays a central role by being recruited to rDNA and by targeting chromatin modifying enzymes such as HDAC1, leading to repress RNA polymerase I transcription. Recruited to rDNA via its interaction with TTF1 and its ability to recognize and bind histone H4 acetylated on 'Lys- 16' (H4K16ac), leading to deacetylation of H4K5ac, H4K8ac, H4K12ac but not H4K16ac. Specifically binds pRNAs, 150-250 nucleotide RNAs that are complementary in sequence to the rDNA promoter; pRNA- binding is required for heterochromatin formation and rDNA silencing (By similarity). {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Milciclib 2μM R08 exp502	-2.06
RO-3307 4.7μM R02 exp80	-1.89
Atovaquone 15μM R08 exp451	-1.8
ABT-702 5μM R07 exp318	-1.73
Radicicol 0.16μM R05 exp242	1.75
Geldanamycin 0.015 to 0.025μM on day4 R07 exp316	1.82
Ribavirin 10 to 15μM on day4 R04 exp160	1.89
GSK-LSD1 10μM R03 exp123	1.95
ETC-159 50μM R08 exp480	2.25
S-trityl-L-cysteine 0.5μM R05 exp243	2.38

Global Fraction of Cell Lines Where Essential: 0/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/25
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/15
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/14
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/7
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

rDNA heterochromatin
chromatin silencing complex
RNA polymerase I CORE element sequence-specific DNA binding
RNA polymerase I preinitiation complex assembly
chromatin silencing at rDNA
lysine-acetylated histone binding
nuclear receptor binding
transcription preinitiation complex assembly
transcription initiation from RNA polymerase I promoter
transcription by RNA polymerase I
DNA alkylation
DNA methylation
histone deacetylation
protein deacetylation
chromatin organization involved in negative regulation of transcription
chromatin silencing
protein deacylation
macromolecule deacylation
DNA methylation or demethylation
chromatin organization involved in regulation of transcription
negative regulation of gene expression, epigenetic
DNA modification
histone binding
gene silencing
chromatin remodeling
protein-DNA complex assembly
DNA-templated transcription, initiation
regulation of gene expression, epigenetic
protein-DNA complex subunit organization
macromolecule methylation
methylation
histone modification
covalent chromatin modification
nuclear speck
transcription, DNA-templated
nucleic acid-templated transcription
RNA biosynthetic process
chromatin organization
DNA metabolic process
cellular protein-containing complex assembly